Bromide

Bromide

SCHEMBL8664990

CCCC=C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Br-]

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 1/20 0.39
CYP1A2 P05177 10/20 0.36
TSHR P16473 10/20 0.36
CYP2C19 P33261 9/20 0.36
CYP3A4 P08684 8/20 0.36
CYP2C9 P11712 8/20 0.36
ALDH1A1 P00352 5/20 0.36
GABBR2 O75899 1/20 0.35
GABBR1 Q9UBS5 1/20 0.35
CYP2D6 P10635 5/20 0.35
SMN1; SMN2 Q16637 4/20 0.33
LMNA P02545 1/20 0.33
TLR8 Q9NR97 1/20 0.33
TP53 P04637 2/20 0.31
MAPT P10636 1/20 0.31
MAPK1 P28482 1/20 0.31
KDM4E B2RXH2 1/20 0.31
HSD17B10 Q99714 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL8664989 1.00 HIF1A (0.39) HIF1ACYP1A2TSHRCYP2C19CYP3A4
Bromide SCHEMBL9460664 0.88 CYP1A2 (0.47) CYP1A2TSHRCYP2C19CYP3A4CYP2C9
Bromide SCHEMBL9460670 0.88 CYP1A2 (0.47) CYP1A2TSHRCYP2C19CYP3A4CYP2C9
Bromide SCHEMBL552222 0.86 CYP3A4 (0.42) CYP1A2TSHRCYP2C19CYP3A4CYP2C9
Iodide SCHEMBL4819097 0.82 CYP1A2 (0.42) CYP1A2TSHRCYP2C19CYP3A4CYP2C9
Iodide SCHEMBL10731914 0.81 SOAT2 (0.44) CYP1A2TSHRCYP2C19CYP3A4CYP2C9
Bromide SCHEMBL8441240 0.79 HIF1A (0.50) HIF1ACYP1A2TSHRCYP2C19ALDH1A1
Bromide SCHEMBL8441246 0.79 HIF1A (0.50) HIF1ACYP1A2TSHRCYP2C19ALDH1A1
Bromide SCHEMBL9594082 0.76 HIF1A (0.46) HIF1ACYP1A2TSHRCYP2C19ALDH1A1
Bromide SCHEMBL9594079 0.76 HIF1A (0.46) HIF1ACYP1A2TSHRCYP2C19ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5808126-A RING OPENING METATHESIS POLYMERIZATION; SILYLATION, CATALYSIS, ENDCAPPING DOW CORNING CORPORATION (US) 1998-09-15 US disclosed