Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 6/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.42 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.41 |
| ▸ | FAAH | O00519 | 4/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL10731914 | 0.98 | SOAT2 (0.44) | CYP1A2CYP3A4CYP2C9CYP2C19TSHR | |
| Bromide SCHEMBL552222 | 0.96 | CYP3A4 (0.42) | CYP1A2CYP3A4CYP2C9CYP2C19TSHR | |
| Bromide SCHEMBL9460664 | 0.91 | CYP1A2 (0.47) | CYP1A2CYP3A4CYP2C9CYP2C19TSHR | |
| Bromide SCHEMBL9460670 | 0.91 | CYP1A2 (0.47) | CYP1A2CYP3A4CYP2C9CYP2C19TSHR | |
| Bromide SCHEMBL8664990 | 0.82 | HIF1A (0.39) | CYP1A2CYP3A4CYP2C9CYP2C19TSHR | |
| Bromide SCHEMBL8664989 | 0.82 | HIF1A (0.39) | CYP1A2CYP3A4CYP2C9CYP2C19TSHR | |
| Iodide SCHEMBL8438793 | 0.82 | HIF1A (0.47) | SOAT2SOAT1FAAHEPHX2CNR1 | |
| Iodide SCHEMBL8438790 | 0.82 | HIF1A (0.47) | SOAT2SOAT1FAAHEPHX2CNR1 | |
| SCHEMBL9844662 | 0.79 | NR1I2 (0.41) | CYP1A2CYP3A4CYP2C9CYP2C19TSHR | |
| Iodide SCHEMBL10731909 | 0.79 | HIF1A (0.47) | CYP1A2CYP3A4CYP2C19TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358221-B1 | Metathesis depolymerizable surfactants | SANDIA CORPORATION (US) | 2008-04-15 | — | — | US | disclosed |