SCHEMBL8665022

SCHEMBL8665022

CCOC(=O)c1c[nH]cc1-c1ccc(Cl)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKCZ Q05513 1/20 0.52
SMN1; SMN2 Q16637 3/20 0.52
NPC1 O15118 2/20 0.52
LMNA P02545 2/20 0.52
RAB9A P51151 2/20 0.52
POLB P06746 1/20 0.52
GCGR P47871 1/20 0.50
ALPL P05186 1/20 0.50
ABCC1 P33527 1/20 0.50
CACNA1D Q01668 2/20 0.49
HSD17B10 Q99714 1/20 0.48
HPGD P15428 3/20 0.48
KDM4E B2RXH2 2/20 0.48
ALDH1A1 P00352 2/20 0.48
MEN1 O00255 1/20 0.48
KMT2A Q03164 1/20 0.48
TP53 P04637 2/20 0.48
MDM2 Q00987 1/20 0.48
MAPK1 P28482 1/20 0.48
TARBP2 Q15633 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15334465 0.90 SMN1; SMN2 (0.49) PRKCZSMN1; SMN2NPC1LMNARAB9A
SCHEMBL2673120 0.88 ALDH1A1 (0.50) SMN1; SMN2LMNARAB9AHSD17B10HPGD
SCHEMBL4491165 0.85 ALDH1A1 (0.55) PRKCZSMN1; SMN2NPC1LMNARAB9A
SCHEMBL6164247 0.85 HTT (0.50) SMN1; SMN2NPC1LMNARAB9ACACNA1D
SCHEMBL6976375 0.85 TSHR (0.46) PRKCZSMN1; SMN2NPC1LMNARAB9A
SCHEMBL4042415 0.84 TSHR (0.58) SMN1; SMN2NPC1LMNARAB9AHSD17B10
SCHEMBL328001 0.82 TSHR (0.44) PRKCZSMN1; SMN2NPC1LMNARAB9A
SCHEMBL276323 0.80 AR (0.56) PRKCZSMN1; SMN2RAB9ACACNA1DMAPT
SCHEMBL27971326 0.80 PRKCZ (0.56) PRKCZSMN1; SMN2LMNARAB9AHSD17B10
SCHEMBL15334383 0.78 ALDH1A1 (0.50) SMN1; SMN2HPGDKDM4EALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5739155-A Haloalkylthio,-sulfinyl and -sulfonyl arylpyrrole insecticidal and acaricidal agents AMERICAN CYANAMID CO. (US) 1998-04-14 US disclosed
EP-0549866-B1 Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole insecticidal, acaricidal and fungicidal agents AMERICAN CYANAMID CO (US) 1997-08-13 EP disclosed
US-5484807-A Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole insecticidal and acaricidal agents BASF AKTIENGESELLSCHAFT 1996-01-16 US disclosed
US-5468877-A FOR PROTECTING CROPS AMERICAN CYANAMID COMPANY (US) 1995-11-21 US disclosed
US-5455263-A Administering substituted arylpyrrole compounds AMERICAN CYANAMID COMPANY (US) 1995-10-03 US disclosed
US-5310938-A Miticides, insecticides, parasiticides, and anthelmintics AMERICAN CYANAMID COMPANY (US) 1994-05-10 US disclosed
US-5306827-A Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole insecticidal and acaricidal agents AMERICAN CYANAMID COMPANY (US) 1994-04-26 US disclosed
US-5284863-A Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole fungicidal agents AMERICAN CYANAMID COMPANY (US) 1994-02-08 US disclosed
EP-0312723-B1 Method of and bait compositions for controlling mollusks AMERICAN CYANAMID CO (US) 1993-12-22 EP disclosed
EP-0549866-A1 Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole insecticidal, acaricidal and fungicidal agents AMERICAN CYANAMID COMPANY (US) 1993-07-07 EP disclosed
US-5010098-A Arylpyrrole insecticidal acaricidal and nematicidal agents and methods for the preparation thereof AMERICAN CYANAMID COMPANY (US) 1991-04-23 US disclosed
US-4929634-A ARYLPYRROLE COMPOUNDS AMERICAN CYANAMID COMPANY (US) 1990-05-29 US disclosed
EP-0358047-A2 Method of controlling phytopathogenic fungi AMERICAN CYANAMID COMPANY (US) 1990-03-14 EP disclosed
EP-0347488-A1 Arylpyrrole insecticidal acaricidal and nematicidal agents and method for the preparation thereof AMERICAN CYANAMID COMPANY (US) 1989-12-27 EP disclosed
EP-0312723-A2 Method of and bait compositions for controlling mollusks AMERICAN CYANAMID COMPANY (US) 1989-04-26 EP disclosed