⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL455193 | 1.00 | — | — | |
| SCHEMBL232854 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL712887 | 0.98 | PPARG (0.36) | — | |
| SCHEMBL9480599 | 0.85 | SOAT1 (0.38) | — | |
| SCHEMBL9480609 | 0.85 | SOAT1 (0.38) | — | |
| SCHEMBL29957177 | 0.84 | S1PR1 (0.38) | — | |
| SCHEMBL865038 | 0.82 | GRIK1 (0.50) | — | |
| SCHEMBL866402 | 0.82 | GRIK1 (0.50) | — | |
| SCHEMBL11694674 | 0.79 | — | — | |
| SCHEMBL526332 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140255991-A1 | OVEREXPRESSION OF AMINOACYL-tRNA SYNTHETASES FOR EFFICIENT PRODUCTION OF ENGINEERED PROTEINS CONTAINING AMINO ACID ANALOGUES | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2014-09-11 | — | — | US | claimed |
| EP-2444499-A2 | Amino acid substituted molecules | Allozyne, Inc. (US) | 2012-04-25 | — | — | EP | claimed |
| US-20120077228-A1 | OVEREXPRESSION OF AMINOACYL-tRNA SYNTHETASES FOR EFFICIENT PRODUCTION OF ENGINEERED PROTEINS CONTAINING AMINO ACID ANALOGUES | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2012-03-29 | — | — | US | claimed |
| US-7723070-B2 | Adding an desired amino acid analog to a medium containing a host cell with a vector coding for aminoacyl-tRNA synthetase and a vector coding for the polypeptide of interest; and growing the cell to produce the modified polypeptide | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2010-05-25 | — | — | US | claimed |
| US-20080160609-A1 | Dihydrofolate reductase; site directed mutagenesis; point mutations; auxotroph host cells | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2008-07-03 | — | — | US | claimed |
| US-7198915-B2 | Preparing modified/artificial polypeptides; mimetics | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2007-04-03 | — | — | US | claimed |
| US-20040058415-A1 | Preparing modified/artificial polypeptides; mimetics | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2004-03-25 | — | — | US | claimed |
| US-6586207-B2 | Host cell is a methionine auxotroph; methionine-tRNA synthetase overexpressed in presence of analogues and absence of methionine; protein is modified dihydrofolate reductase | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2003-07-01 | — | — | US | claimed |
| US-20020042097-A1 | Host cell is a methionine auxotroph; methionine-tRNA synthetase overexpressed in presence of analogues and absence of methionine; protein is modified dihydrofolate reductase | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2002-04-11 | — | — | US | claimed |
| US-20250242053-A1 | RECOMBINANT THERAPEUTIC FMR1 CONSTRUCTS AND METHODS OF TREATING FRAGILE X SYNDROME AND RELATED DISORDERS | THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2025-07-31 | — | — | US | disclosed |
| US-20250136651-A1 | RECOMBINANT OPTIMIZED MECP2 CASSETTES AND METHODS FOR TREATING RETT SYNDROME AND RELATED DISORDERS | THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2025-05-01 | — | — | US | disclosed |
| EP-4514980-A1 | RECOMBINANT THERAPEUTIC FMR1 CONSTRUCTS AND METHODS OF TREATING FRAGILE X SYNDROME AND RELATED DISORDERS | The University Court Of The University of Edinburgh (GB) | 2025-03-05 | — | — | EP | disclosed |
| WO-2023114816-A9 | RECOMBINANT OPTIMIZED GALC CONSTRUCTS AND METHODS FOR TREATING GALC-ASSOCIATED DISORDERS | NEUROGENE INC. (US) | 2025-01-16 | — | — | WO | disclosed |
| EP-4473121-A1 | RECOMBINANT OPTIMIZED MECP2 CASSETTES AND METHODS FOR TREATING RETT SYNDROME AND RELATED DISORDERS | The University Court Of The University of Edinburgh (GB) | 2024-12-11 | — | — | EP | disclosed |
| US-20040058415-A1 | Preparing modified/artificial polypeptides; mimetics | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2004-03-25 | — | — | US | disclosed |
| US-20040058415-A1 | Preparing modified/artificial polypeptides; mimetics | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2004-03-25 | — | — | US | disclosed |
| US-6586207-B2 | Host cell is a methionine auxotroph; methionine-tRNA synthetase overexpressed in presence of analogues and absence of methionine; protein is modified dihydrofolate reductase | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2003-07-01 | — | — | US | disclosed |
| US-6586207-B2 | Host cell is a methionine auxotroph; methionine-tRNA synthetase overexpressed in presence of analogues and absence of methionine; protein is modified dihydrofolate reductase | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2003-07-01 | — | — | US | disclosed |
| US-20020042097-A1 | Host cell is a methionine auxotroph; methionine-tRNA synthetase overexpressed in presence of analogues and absence of methionine; protein is modified dihydrofolate reductase | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2002-04-11 | — | — | US | disclosed |
| US-20020042097-A1 | Host cell is a methionine auxotroph; methionine-tRNA synthetase overexpressed in presence of analogues and absence of methionine; protein is modified dihydrofolate reductase | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2002-04-11 | — | — | US | disclosed |