Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 7/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.34 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8665525 | 0.98 | CCR3 (0.40) | CCR3LMNAMAPTKDM5AHTR7 | |
| SCHEMBL8717983 | 0.96 | CCR3 (0.43) | CCR3LMNAMAPTKDM5AHTR7 | |
| SCHEMBL8712537 | 0.94 | CCR3 (0.43) | CCR3LMNAMAPTKDM5AHTR7 | |
| SCHEMBL8666998 | 0.90 | CCR3 (0.40) | CCR3KDM5AHTR7HTR1ADRD2 | |
| SCHEMBL8665880 | 0.89 | UTS2R (0.39) | DRD2MTNR1AMTNR1BNPSR1 | |
| SCHEMBL8664869 | 0.88 | SMPD3 (0.38) | KDM5AMTNR1AMTNR1B | |
| SCHEMBL8666092 | 0.87 | UTS2R (0.39) | DRD2MTNR1AMTNR1BNPSR1 | |
| SCHEMBL8668018 | 0.86 | MAPT (0.39) | CCR3LMNAMAPTHTR7HTR1A | |
| SCHEMBL8524381 | 0.86 | CCR3 (0.42) | CCR3MAPTKDM5AHTR7HTR1A | |
| SCHEMBL8482395 | 0.85 | MAPT (0.38) | CCR3LMNAMAPTKDM5AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5827875-A | PYRROLIDINE DERIVATIVES; ANTIATHEROSCLEROSIS AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-10-27 | — | — | US | claimed |
| US-5827875-A | PYRROLIDINE DERIVATIVES; ANTIATHEROSCLEROSIS AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-10-27 | — | — | US | disclosed |