Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 8/20 | 0.34 |
| ▸ | FPR1 | P21462 | 7/20 | 0.34 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8665488 | 0.90 | CCR2 (0.37) | FPR2FPR1HTR1A | |
| SCHEMBL8717983 | 0.87 | CCR3 (0.43) | MAPTLMNACCR3NPSR1L3MBTL1 | |
| SCHEMBL8482395 | 0.87 | MAPT (0.38) | MAPTLMNACCR3NPSR1L3MBTL1 | |
| SCHEMBL8665515 | 0.86 | CCR3 (0.41) | MAPTLMNACCR3NPSR1L3MBTL1 | |
| SCHEMBL8712537 | 0.85 | CCR3 (0.43) | MAPTLMNACCR3NPSR1L3MBTL1 | |
| SCHEMBL8665525 | 0.84 | CCR3 (0.40) | MAPTLMNACCR3NPSR1L3MBTL1 | |
| SCHEMBL8668024 | 0.82 | CCR3 (0.35) | MAPTLMNACCR3NPSR1L3MBTL1 | |
| SCHEMBL8577127 | 0.80 | LMNA (0.41) | MAPTLMNANPSR1L3MBTL1TSHR | |
| SCHEMBL8668022 | 0.80 | FPR1 (0.36) | CCR3NPSR1L3MBTL1FPR2FPR1 | |
| SCHEMBL8485062 | 0.80 | MAPT (0.40) | MAPTLMNACCR3NPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5827875-A | PYRROLIDINE DERIVATIVES; ANTIATHEROSCLEROSIS AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-10-27 | — | — | US | claimed |