Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | APAF1 | O14727 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | TP53 | P04637 | 4/20 | 0.53 |
| ▸ | BLM | P54132 | 2/20 | 0.53 |
| ▸ | TDP2 | O95551 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.53 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8667772 | 0.91 | ADORA1 (0.46) | MAPTKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL8671673 | 0.87 | MAPT (0.63) | MAPTKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL8666934 | 0.86 | ADORA1 (0.55) | MAPTKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL8667035 | 0.85 | MAPT (0.45) | MAPTKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL8668405 | 0.85 | HDAC1 (0.42) | MAPTKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL8665872 | 0.82 | ADORA1 (0.41) | MAPTKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL4957609 | 0.81 | ADORA1 (0.66) | MAPTKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL1822988 | 0.80 | MAPT (0.70) | MAPTKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL8667667 | 0.79 | ADORA1 (0.54) | MAPTKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL8666532 | 0.79 | MAPT (0.52) | MAPTKMT2AALDH1A1MEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638581-B1 | PHOSPHONIC DIESTER DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 1998-12-23 | — | — | EP | claimed |
| US-5480874-A | THIAZOLE AND IMIDAZOLE DERIVATIVES; ANTIHYPERLIPIDEMICS AND HYPOGLYCEMICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1996-01-02 | — | — | US | claimed |
| EP-0638581-A1 | PHOSPHONIC DIESTER DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1995-02-15 | — | — | EP | claimed |
| EP-0638581-B1 | PHOSPHONIC DIESTER DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 1998-12-23 | — | — | EP | disclosed |
| US-5480874-A | THIAZOLE AND IMIDAZOLE DERIVATIVES; ANTIHYPERLIPIDEMICS AND HYPOGLYCEMICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1996-01-02 | — | — | US | disclosed |
| EP-0638581-A1 | PHOSPHONIC DIESTER DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1995-02-15 | — | — | EP | disclosed |