Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 10/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | APAF1 | O14727 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | TDP2 | O95551 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8665878 | 0.91 | MAPT (0.54) | ADORA1ADORA2AMAPTALDH1A1KMT2A | |
| SCHEMBL8666532 | 0.88 | MAPT (0.52) | MAPTALDH1A1KMT2AMEN1APAF1 | |
| SCHEMBL8666187 | 0.86 | MAPT (0.37) | MAPTALDH1A1KMT2AMEN1APAF1 | |
| SCHEMBL8673476 | 0.85 | CCNT1 (0.36) | ADORA1ADORA2AMAPTALDH1A1KMT2A | |
| SCHEMBL8665872 | 0.83 | ADORA1 (0.41) | ADORA1ADORA2AMAPTALDH1A1KMT2A | |
| SCHEMBL8666340 | 0.79 | MAPT (0.42) | MAPTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL8671673 | 0.79 | MAPT (0.63) | MAPTALDH1A1KMT2AMEN1APAF1 | |
| SCHEMBL8667035 | 0.77 | MAPT (0.45) | MAPTALDH1A1KMT2AMEN1APAF1 | |
| SCHEMBL8666934 | 0.77 | ADORA1 (0.55) | ADORA1ADORA2AMAPTALDH1A1KMT2A | |
| SCHEMBL8668405 | 0.76 | HDAC1 (0.42) | MAPTALDH1A1KMT2AMEN1APAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638581-B1 | PHOSPHONIC DIESTER DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 1998-12-23 | — | — | EP | disclosed |
| US-5480874-A | THIAZOLE AND IMIDAZOLE DERIVATIVES; ANTIHYPERLIPIDEMICS AND HYPOGLYCEMICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1996-01-02 | — | — | US | disclosed |
| EP-0638581-A1 | PHOSPHONIC DIESTER DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1995-02-15 | — | — | EP | disclosed |