Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8666938 | 0.96 | PNMT (0.33) | PNMT | |
| Hydrochloric Acid SCHEMBL8679932 | 0.77 | PNMT (0.37) | PNMTDRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL8581356 | 0.75 | CYSLTR2 (0.30) | — | |
| Hydrochloric Acid SCHEMBL9167880 | 0.74 | PNMT (0.36) | PNMTDRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL8670537 | 0.74 | — | — | |
| SCHEMBL7607951 | 0.74 | PNMT (0.39) | PNMTDRD2DRD4DRD3 | |
| SCHEMBL62724 | 0.74 | PNMT (0.39) | PNMTDRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL8670986 | 0.74 | PNMT (0.34) | PNMTDRD2DRD4DRD3 | |
| SCHEMBL6675362 | 0.73 | PNMT (0.38) | PNMTDRD2DRD4DRD3 | |
| SCHEMBL6675358 | 0.73 | PNMT (0.38) | PNMTDRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5744666-A | Process for preparing an alkynyl fulvene group containing compound and said compound | PHILLIPS PETROLEUM COMPANY (US) | 1998-04-28 | — | — | US | disclosed |
| US-5728908-A | Process for preparing a bridged ligand and said bridged ligand | PHILLIPS PETROLEUM COMPANY (US) | 1998-03-17 | — | — | US | disclosed |
| US-5631203-A | Metallocene compounds and preparation thereof containing terminal alkynes | PHILLIPS PETROLEUM COMPANY (US) | 1997-05-20 | — | — | US | disclosed |