Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8667533 | 1.00 | HTT (0.42) | HTTSMN1; SMN2KDM4EMEN1NPC1 | |
| SCHEMBL9000584 | 0.77 | PTGS1 (0.34) | — | |
| SCHEMBL9000591 | 0.77 | PTGS1 (0.34) | — | |
| SCHEMBL8665745 | 0.74 | KDM4E (0.43) | HTTSMN1; SMN2KDM4EMEN1NPC1 | |
| SCHEMBL8665743 | 0.74 | KDM4E (0.43) | HTTSMN1; SMN2KDM4EMEN1NPC1 | |
| SCHEMBL8665747 | 0.74 | KDM4E (0.43) | HTTSMN1; SMN2KDM4EMEN1NPC1 | |
| SCHEMBL30284405 | 0.72 | KDM4E (0.50) | HTTSMN1; SMN2KDM4EMEN1NPC1 | |
| SCHEMBL361847 | 0.72 | KDM4E (0.50) | HTTSMN1; SMN2KDM4EMEN1NPC1 | |
| SCHEMBL5645944 | 0.72 | ACHE (0.35) | KDM4EMEN1NPC1ALDH1A1LMNA | |
| SCHEMBL13998235 | 0.70 | KDM4E (0.37) | HTTSMN1; SMN2KDM4EMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662968-B1 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES INC (US) | 1998-12-02 | — | — | EP | disclosed |
| EP-0662968-A1 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES, INC. (US) | 1995-07-19 | — | — | EP | disclosed |
| EP-0662968-A4 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS. | PPG INDUSTRIES INC (US) | 1995-04-12 | — | — | EP | disclosed |
| WO-1994007889-A1 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES, INC. (US) | 1994-04-14 | — | — | WO | disclosed |
| US-5274132-A | Photochromic naphthopyran compounds | TRANSITIONS OPTICAL, INC. (US) | 1993-12-28 | — | — | US | disclosed |