SCHEMBL8668

SCHEMBL8668

Cc1cccc2nc[nH]c12

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 6/20 0.56
BRD4 O60885 1/20 0.41
ACP1 P24666 1/20 0.40
PDPK1 O15530 1/20 0.39
CA12 O43570 1/20 0.39
ALOX15 P16050 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
CA9 Q16790 1/20 0.39
TNKS2 Q9H2K2 1/20 0.39
AR P10275 1/20 0.39
TAAR1 Q96RJ0 1/20 0.39
PIK3CD O00329 1/20 0.36
AHR P35869 1/20 0.36
KDM4E B2RXH2 1/20 0.35
ALDH1A1 P00352 1/20 0.35
GLA P06280 1/20 0.35
GAA P10253 1/20 0.35
HPGD P15428 1/20 0.35
HSD17B10 Q99714 1/20 0.35
KIF11 P52732 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11468187 0.98 PARP1 (0.55) PARP1BRD4ACP1PDPK1CA12
SCHEMBL196912 0.77 PARP1 (0.42) PARP1BRD4PDPK1CA12ALOX15
SCHEMBL3232202 0.76 PARP1 (0.41) PARP1PDPK1CA12ALOX15SMN1; SMN2
SCHEMBL30036694 0.74 PARP1 (0.43) PARP1PDPK1CA12ALOX15SMN1; SMN2
SCHEMBL1019602 0.74 QPCT (0.42) PARP1PDPK1CA12ALOX15SMN1; SMN2
SCHEMBL29503821 0.74 PARP1 (0.39) PARP1BRD4ACP1PDPK1SMN1; SMN2
SCHEMBL196737 0.74 PARP1 (0.56) PARP1ACP1PDPK1CA12ALOX15
SCHEMBL312428 0.74 PARP1 (0.43) PARP1PDPK1CA12ALOX15SMN1; SMN2
SCHEMBL4130388 0.74 PARP1 (0.56) PARP1PDPK1CA12ALOX15SMN1; SMN2
SCHEMBL1445123 0.74 PDPK1 (0.41) PARP1PDPK1CA12ALOX15SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2009 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119563048-A Passivation coating on copper metal surfaces for copper wire bonding applications 北德克萨斯大学 2025-03-04 CN claimed
WO-2024201393-A1 METHODS FOR THE SYNTHESIS OF NUCLEOSIDE ANALOGUES AND NUCLEOSIDES ANALOGUES DERIVED THEREFROM SIMON FRASER UNIVERSITY (CA) 2024-10-03 WO claimed
US-20240254546-A1 COMPOSITIONS AND METHODS FOR NUCLEIC ACID AMPLIFICATION AMPLIWISE INC. (US) 2024-08-01 US claimed
EP-4090768-B1 COMPOSITIONS, KITS AND METHODS FOR ISOLATING TARGET POLYNUCLEOTIDES DNAE DIAGNOSTICS LTD (GB) 2024-03-13 EP claimed
US-11827925-B2 Compositions and methods for nucleic acid amplification AMPLIWISE INC. (US) 2023-11-28 US claimed
CN-117106189-A Metal organic framework artificial hydrolase and preparation method and application thereof 华南理工大学 2023-11-24 CN claimed
CN-116606685-A Water-soluble temper rolling liquid composition for non-degreased annealed steel sheet 大同化学株式会社 2023-08-18 CN claimed
CN-114457145-B Linkers, constructs, methods and uses for characterizing target polynucleotide sequencing 成都齐碳科技有限公司 2023-08-11 CN claimed
WO-2023143247-A1 LINKER FOR CHARACTERIZING SEQUENCING OF TARGET POLYNUCLEOTIDE, CONSTRUCT, METHOD, AND USE 成都齐碳科技有限公司 2023-08-03 WO claimed
US-11697812-B2 Methods and compositions for the specific inhibition of transthyretin (TTR) by double-stranded RNA DICERNA PHARMACEUTICALS, INC. (US) 2023-07-11 US claimed
EP-3234132-A1 LIGAND-MODIFIED DOUBLE-STRANDED NUCLEIC ACIDS Dicerna Pharmaceuticals, Inc. (US) 2017-10-25 EP claimed
WO-2016100401-A1 LIGAND-MODIFIED DOUBLE-STRANDED NUCLEIC ACIDS DICERNA PHARMACEUTICALS, INC. (US) 2016-06-23 WO claimed
US-20150038554-A1 Extended Dicer Substrate Agents and Methods for the Specific Inhibition of Gene Expression NOVO NORDISK A/S (DK) 2015-02-05 US claimed
US-20150038555-A1 Extended Dicer Substrate Agents and Methods for the Specific Inhibition of Gene Expression NOVO NORDISK A/S (DK) 2015-02-05 US claimed
US-20130041010-A1 COMPOSITIONS AND METHODS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DSRNA CONTAINING MODIFIED NUCLEOTIDES DICERNA PHARMACEUTICALS, INC. (US) 2013-02-14 US claimed
US-20110288147-A1 Compositions and methods for the specific inhibition of gene expression by DSRNA containing a tetraloop DICERNA PHARMACEUTICALS, INC. 2011-11-24 US claimed
EP-2341943-A2 COMPOSITIONS AND METHODS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DSRNA POSSESSING MODIFICATIONS Dicerna Pharmaceuticals, Inc. (US) 2011-07-13 EP claimed
WO-2011033235-A1 COMPOSITE MATERIAL COMPRISING AN ORGANIC-INORGANIC MATERIAL, PREPARATION PROCESS, AND USES TREDI (FR) 2011-03-24 WO claimed
US-20100331389-A1 Compositions and methods for the specific inhibition of gene expression by dsRNA containing modified nucleotides DICERNA PHARMACEUTICALS, INC. 2010-12-30 US claimed
WO-2010033225-A2 COMPOSITIONS AND METHODS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DSRNA POSSESSING MODIFICATIONS DICERNA PHARMACEUTICALS, INC. (US) 2010-03-25 WO claimed