Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | LTK | P29376 | 1/20 | 0.43 |
| ▸ | GRK5 | P34947 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL196912 | 0.77 | PARP1 (0.42) | PARP1ABL1ACVR1ALOX15PDPK1 | |
| SCHEMBL3232202 | 0.76 | PARP1 (0.41) | PARP1ABL1CLK2GSK3BDYRK1A | |
| SCHEMBL30036694 | 0.74 | PARP1 (0.43) | PARP1LRRK2ALOX15PDPK1CA12 | |
| SCHEMBL4130388 | 0.74 | PARP1 (0.56) | PARP1CDK5ALOX15PDPK1CA12 | |
| SCHEMBL1445123 | 0.74 | PDPK1 (0.41) | PARP1PIM1GSK3BCDK9CDK5 | |
| SCHEMBL1019602 | 0.74 | QPCT (0.42) | PARP1FGFR1ALOX15PDPK1CA12 | |
| SCHEMBL29805281 | 0.74 | CSNK2A1 (0.39) | PARP1AURKADAPK3PRKD3MAP4K4 | |
| SCHEMBL4535251 | 0.74 | CSNK2A1 (0.39) | PARP1AURKADAPK3PRKD3MAP4K4 | |
| SCHEMBL312428 | 0.74 | PARP1 (0.43) | PARP1LRRK2ALOX15PDPK1CA12 | |
| SCHEMBL8668 | 0.74 | PARP1 (0.56) | PARP1AHRACP1ALOX15PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3720843-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2020-10-14 | — | — | EP | claimed |
| US-20200291008-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-09-17 | — | — | US | claimed |
| CN-111417626-A | Modulators of indoleamine2,3-dioxygenase | 葛兰素史克知识产权开发有限公司 | 2020-07-14 | — | — | CN | claimed |
| WO-2019111107-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-06-13 | — | — | WO | claimed |
| US-20100087478-A1 | HIF-1 Inhibitors | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-08 | — | — | US | claimed |
| WO-2024163380-A1 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS USEFUL AS INHIBITORS OF TLR9 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-08-08 | — | — | WO | disclosed |
| US-20240025861-A1 | METHODS OF COUPLING A CARBON CONTAINING MOIETY TO AN AMINE CONTAINING MOIETY | PURDUE RESEARCH FOUNDATION | 2024-01-25 | — | — | US | disclosed |
| US-11787770-B2 | Methods of coupling a carbon containing moiety to an amine containing moiety | PURDUE RESEARCH FOUNDATION (US) | 2023-10-17 | — | — | US | disclosed |
| US-20210363111-A1 | METHODS OF COUPLING A CARBON CONTAINING MOIETY TO AN AMINE CONTAINING MOIETY | PURDUE RESEARCH FOUNDATION | 2021-11-25 | — | — | US | disclosed |
| EP-3720843-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2020-10-14 | — | — | EP | disclosed |
| US-20200291008-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-09-17 | — | — | US | disclosed |
| CN-111417626-A | Modulators of indoleamine2,3-dioxygenase | 葛兰素史克知识产权开发有限公司 | 2020-07-14 | — | — | CN | disclosed |
| EP-0395069-A2 | Silver halide photographic materials | FUJI PHOTO FILM CO., LTD. (JP) | 1990-10-31 | — | — | EP | disclosed |
| EP-0393720-A2 | Silver halide photographic materials | FUJI PHOTO FILM CO., LTD. (JP) | 1990-10-24 | — | — | EP | disclosed |
| EP-0335319-A2 | Silver halide photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1989-10-04 | — | — | EP | disclosed |
| US-4737442-A | INCLUDING A SENSITIZER AND A BLOCKED DEVELOPMENT RESTRAINER; FREE OF BLACK SPOTS | FUJI PHOTO FILM CO., LTD. (JP) | 1988-04-12 | — | — | US | disclosed |
| US-4585472-A | PRE- AND POSTEMERGENCE HERBICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1986-04-29 | — | — | US | disclosed |
| US-4030926-A | Light-sensitive material containing a dye-forming combination of a heterocyclic compound and a cyclic dihalodicarbonyl compound in a polymeric binder | AGFA-GEVAERT, A.G. (DT) | 1977-06-21 | — | — | US | disclosed |
| US-3988155-A | CYANINE SENSITIZING DYES | FUJI PHOTO FILM CO., LTD. (JA) | 1976-10-26 | — | — | US | disclosed |
| US-3985563-A | Silver halide photographic emulsion | FUJI PHOTO FILM CO., LTD. (JA) | 1976-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210363111-A1 | METHODS OF COUPLING A CARBON CONTAINING MOIETY TO AN AMINE CONTAINING MOIETY | HCCS, PAICS, PNMT | PARP1 528/4885AURKA 71/4885DAPK3 3251/4885 |
| US-11787770-B2 | Methods of coupling a carbon containing moiety to an amine containing moiety | HCCS, PAICS, PNMT | PARP1 528/4885AURKA 71/4885DAPK3 3251/4885 |
| US-20240025861-A1 | METHODS OF COUPLING A CARBON CONTAINING MOIETY TO AN AMINE CONTAINING MOIETY | HCCS, PAICS, PNMT | PARP1 528/4885AURKA 71/4885DAPK3 3251/4885 |
| US-20100087478-A1 | HIF-1 Inhibitors | HIF1AN, HIF1A, EGLN2 | PARP1 1198/4885AURKA 4372/4885DAPK3 1186/4885 |
| US-20200291008-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | IDO1, IDO2, TPH1 | PARP1 1977/4885AURKA 3368/4885DAPK3 1702/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.