SCHEMBL8668265

SCHEMBL8668265

O=C(O)CCCN1[C@@H]2CCC[C@@]1(OC(=O)c1ccccc1)CC2

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 1/20 0.39
CHRM4 P08173 1/20 0.39
CHRM1 P11229 1/20 0.39
CHRM3 P20309 1/20 0.39
CHRNA7 P36544 3/20 0.37
CHRNB2 P17787 1/20 0.37
CHRNA5 P30532 1/20 0.37
CHRNA4 P43681 1/20 0.37
BACE1 P56817 1/20 0.36
BACE2 Q9Y5Z0 1/20 0.36
HTR3E A5X5Y0 1/20 0.36
HTR3B O95264 1/20 0.36
HTR3A P46098 1/20 0.36
HTR3D Q70Z44 1/20 0.36
HTR3C Q8WXA8 1/20 0.36
SCN1A P35498 1/20 0.36
SCN2A Q99250 1/20 0.36
SCN3A Q9NY46 1/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27917124 0.80 CHRM2 (0.46) CHRM2CHRM4CHRM1CHRM3CHRNA7
SCHEMBL9640284 0.80 CHRM2 (0.46) CHRM2CHRM4CHRM1CHRM3CHRNA7
SCHEMBL1851579 0.68 KMT2A (0.39) SCN1ASCN2ASCN3AMEN1KMT2A
SCHEMBL5790059 0.65 ALDH1A1 (0.40) KMT2A
SCHEMBL467252 0.64 CYP1A2 (0.45) HTR3EHTR3BHTR3AHTR3DHTR3C
SCHEMBL6017223 0.64 CYP2D6 (0.46) CHRNA7CHRNB2CHRNA5CHRNA4HTR3E
SCHEMBL7497538 0.62 CHRNA7 (0.46) CHRM2CHRM4CHRM1CHRM3CHRNA7
SCHEMBL7497532 0.62 CHRNA7 (0.46) CHRM2CHRM4CHRM1CHRM3CHRNA7
SCHEMBL374008 0.62 LMNA (0.47) KMT2A
SCHEMBL7596827 0.61 LMNA (0.39) CHRM2CHRM4CHRM1CHRM3CHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5817770-A N-METHYLTROPANE, 2-CARBOXYETHYL- OR N-ETHYLCARBOXAMIDE, 3-BENZOYLOXY- OR BENZAMIDO- DRUG ABUSE SCIENCES, INC. (US) 1998-10-06 US claimed