Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 13/20 | 0.46 |
| ▸ | RARA | P10276 | 11/20 | 0.46 |
| ▸ | RARG | P13631 | 10/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.43 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8671861 | 0.88 | RARB (0.58) | RARBRARARARGCYP3A4CYP26A1 | |
| SCHEMBL7636118 | 0.86 | RARB (0.49) | RARBRARARARGCYP3A4KMT2A | |
| SCHEMBL8772581 | 0.85 | RARB (0.48) | RARBRARARARGCYP3A4KMT2A | |
| SCHEMBL6708918 | 0.84 | RARA (0.57) | RARBRARARARGCYP3A4KMT2A | |
| SCHEMBL6294126 | 0.82 | RAB9A (0.48) | RARBRARARARGCYP3A4KMT2A | |
| SCHEMBL7640501 | 0.80 | RARB (0.52) | RARBRARARARGCYP3A4KMT2A | |
| SCHEMBL8772517 | 0.80 | RARB (0.48) | RARBRARARARGCYP3A4KMT2A | |
| SCHEMBL8668398 | 0.80 | RARB (0.44) | RARBRARARARGCYP3A4KMT2A | |
| SCHEMBL9484975 | 0.79 | RARB (0.67) | RARBRARARARGCYP3A4KMT2A | |
| SCHEMBL8670048 | 0.76 | RARB (0.48) | RARBRARARARGCYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723620-A | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl groups having retinoid-like biological activity | ALLERGAN (US) | 1998-03-03 | — | — | US | disclosed |
| US-5654469-A | FOR TREATMENT OF SKIN DISORDERS | ALLERGAN (US) | 1997-08-05 | — | — | US | disclosed |
| US-5543534-A | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl groups having retinoid-like biological activity | ALLERGAN | 1996-08-06 | — | — | US | disclosed |
| WO-1996020930-A1 | ACETYLENES DISUBSTITUTED WITH A 5 OR 8 SUBSTITUTED TETRAHYDRONAPHTHYL OR DIHYDRONAPHTHYL GROUP AND WITH AN ARYL OR HETEROARYL GROUPS HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN (US) | 1996-07-11 | — | — | WO | disclosed |