Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8668395 | 1.00 | CASP3 (0.41) | CASP3ALDH1A1POLBGAASMN1; SMN2 | |
| SCHEMBL4581604 | 0.86 | CASP3 (0.51) | CASP3ALDH1A1DRD3CA12CA9 | |
| SCHEMBL30423183 | 0.86 | CASP3 (0.51) | CASP3ALDH1A1DRD3CA12CA9 | |
| SCHEMBL29443002 | 0.86 | CASP3 (0.51) | CASP3ALDH1A1DRD3CA12CA9 | |
| SCHEMBL4581609 | 0.86 | CASP3 (0.51) | CASP3ALDH1A1DRD3CA12CA9 | |
| SCHEMBL4578025 | 0.84 | ALDH1A1 (0.47) | ALDH1A1POLBGAASMN1; SMN2NPSR1 | |
| SCHEMBL4468251 | 0.78 | CASP3 (0.60) | CASP3ALDH1A1DRD3CA12CA9 | |
| SCHEMBL4476083 | 0.78 | CASP3 (0.60) | CASP3ALDH1A1DRD3CA12CA9 | |
| SCHEMBL8950475 | 0.78 | CASP3 (0.60) | CASP3ALDH1A1DRD3CA12CA9 | |
| SCHEMBL7525034 | 0.73 | CASP3 (0.49) | CASP3ALDH1A1DRD3CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811534-A | PURINE-BASED COMPOUNDS FOR INCLUSION INTO OLIGONUCLEOTIDES | ISIS PHARMACEUTICALS, INC. (US) | 1998-09-22 | — | — | US | disclosed |