SCHEMBL8668523

SCHEMBL8668523

O=COc1ccc2[nH]ccc2c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 3/20 0.55
MAOA P21397 2/20 0.48
AHR P35869 3/20 0.46
NR4A2 P43354 2/20 0.46
LTA4H P09960 2/20 0.46
F7 P08709 1/20 0.46
F3 P13726 1/20 0.46
USP2 O75604 1/20 0.46
GAA P10253 1/20 0.46
ALOX15 P16050 1/20 0.46
RAD51 Q06609 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
HDAC1 Q13547 1/20 0.43
IMPDH2 P12268 1/20 0.42
IMPDH1 P20839 1/20 0.42
MEN1 O00255 1/20 0.42
POLB P06746 1/20 0.42
MAPK1 P28482 1/20 0.42
KMT2A Q03164 1/20 0.42
NPC1 O15118 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12133042 0.85 MEN1 (0.59) CYP2A6MAOAAHRLTA4HMEN1
SCHEMBL8763499 0.77 CBFB (0.39) CYP2A6MEN1KMT2AMAPT
SCHEMBL28313946 0.75 CA12 (0.51) MEN1POLBMAPK1KMT2AMAPT
SCHEMBL2807949 0.75 MAOA (0.49) CYP2A6MAOAAHRNR4A2LTA4H
SCHEMBL2807952 0.75 MAOA (0.49) CYP2A6MAOAAHRNR4A2LTA4H
Ethoxycarbonyl Group SCHEMBL28672702 0.75 MAOA (0.52) CYP2A6MAOALTA4HMEN1POLB
SCHEMBL25462527 0.75 AHR (0.50) CYP2A6MAOAAHRNR4A2LTA4H
SCHEMBL6970620 0.75 AHR (0.50) CYP2A6MAOAAHRNR4A2LTA4H
SCHEMBL3871546 0.75 AHR (0.55) CYP2A6MAOAAHRNR4A2LTA4H
SCHEMBL4952881 0.75 AHR (0.55) CYP2A6MAOAAHRNR4A2LTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230358677-A1 Reversible Excited-State Photoacids and Photobases as Dynamic Fluorescence Sensors of Protonic Species CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2023-11-09 US disclosed
US-5792330-A Lanthanide metal cations for concurrent detection and separation in capillary electrophoresis BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1998-08-11 US disclosed
WO-1996038724-A1 LANTHANIDE METAL CATIONS FOR CONCURRENT DETECTION AND SEPARATION IN CAPILLARY ELECTROPHORESIS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1996-12-05 WO disclosed