Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 5/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 5/20 | 0.44 |
| ▸ | GRIA3 | P42263 | 5/20 | 0.44 |
| ▸ | GRIA4 | P48058 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8667341 | 0.87 | GRIA1 (0.45) | GRIA1GRIA2GRIA3GRIA4MAPT | |
| SCHEMBL8671733 | 0.84 | GRIA1 (0.45) | GRIA1GRIA2GRIA3GRIA4MEN1 | |
| SCHEMBL8668928 | 0.83 | GRIA1 (0.52) | GRIA1GRIA2GRIA3GRIA4MAPT | |
| SCHEMBL8668562 | 0.82 | GRIA1 (0.43) | GRIA1GRIA2GRIA3GRIA4RAB9A | |
| SCHEMBL8673721 | 0.81 | ALDH1A1 (0.46) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8669904 | 0.81 | GRIA1 (0.47) | GRIA1GRIA2GRIA3GRIA4EPHX2 | |
| SCHEMBL9232977 | 0.80 | GRIA1 (0.43) | GRIA1GRIA2GRIA3GRIA4APP | |
| Hydrochloric Acid SCHEMBL8671333 | 0.80 | GRIA1 (0.46) | GRIA1GRIA2GRIA3GRIA4MAPT | |
| SCHEMBL8669247 | 0.78 | GRIA1 (0.56) | GRIA1GRIA2GRIA3GRIA4MAPT | |
| SCHEMBL9235550 | 0.78 | GRIA1 (0.43) | GRIA1GRIA2GRIA3GRIA4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996017832-A1 | NOVEL GLUTAMATE RECEPTOR ANTAGONISTS: FUSED CYCLOALKYLQUINOXALINEDIONES | WARNER-LAMBERT COMPANY (US) | 1996-06-13 | — | — | WO | claimed |
| US-5721234-A | TREATING CONVULSIONS, ANXIETY, CEREBRAL HYPOXIA/ISCHEMIA, PARKINSON*S DISEASE | WARNER-LAMBERT COMPANY (US) | 1998-02-24 | — | — | US | disclosed |
| WO-1996017832-A1 | NOVEL GLUTAMATE RECEPTOR ANTAGONISTS: FUSED CYCLOALKYLQUINOXALINEDIONES | WARNER-LAMBERT COMPANY (US) | 1996-06-13 | — | — | WO | disclosed |