Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 4/20 | 0.43 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.43 |
| ▸ | GRIA3 | P42263 | 4/20 | 0.43 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KCNMA1 | Q12791 | 7/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9093233 | 0.92 | KCNMA1 (0.42) | GRIA1GRIA2GRIA3GRIA4KDM4E | |
| SCHEMBL8671733 | 0.91 | GRIA1 (0.45) | GRIA1GRIA2GRIA3GRIA4ALDH1A1 | |
| SCHEMBL8667341 | 0.88 | GRIA1 (0.45) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8673721 | 0.85 | ALDH1A1 (0.46) | GRIA1GRIA2GRIA3GRIA4ALDH1A1 | |
| SCHEMBL8669892 | 0.85 | GRIA1 (0.41) | GRIA1GRIA2GRIA3GRIA4KCNMA1 | |
| SCHEMBL9092722 | 0.83 | GRIA1 (0.44) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL9094360 | 0.83 | GRIA1 (0.43) | GRIA1GRIA2GRIA3GRIA4ALDH1A1 | |
| SCHEMBL8668928 | 0.82 | GRIA1 (0.52) | GRIA1GRIA2GRIA3GRIA4KDM4E | |
| SCHEMBL8671549 | 0.82 | GRIA1 (0.44) | GRIA1GRIA2GRIA3GRIA4KDM4E | |
| SCHEMBL8668931 | 0.82 | GRIA1 (0.44) | GRIA1GRIA2GRIA3GRIA4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996017832-A1 | NOVEL GLUTAMATE RECEPTOR ANTAGONISTS: FUSED CYCLOALKYLQUINOXALINEDIONES | WARNER-LAMBERT COMPANY (US) | 1996-06-13 | — | — | WO | claimed |
| US-5721234-A | TREATING CONVULSIONS, ANXIETY, CEREBRAL HYPOXIA/ISCHEMIA, PARKINSON*S DISEASE | WARNER-LAMBERT COMPANY (US) | 1998-02-24 | — | — | US | disclosed |
| WO-1996017832-A1 | NOVEL GLUTAMATE RECEPTOR ANTAGONISTS: FUSED CYCLOALKYLQUINOXALINEDIONES | WARNER-LAMBERT COMPANY (US) | 1996-06-13 | — | — | WO | disclosed |