Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.48 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.48 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | GLS | O94925 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5849107 | 0.98 | KMT2A (0.53) | KMT2AMEN1L3MBTL1SMN1; SMN2GAA | |
| SCHEMBL7701320 | 0.85 | KMT2A (0.58) | KMT2AMEN1L3MBTL1SMN1; SMN2GAA | |
| SCHEMBL27696449 | 0.83 | HTT (0.57) | KMT2AMEN1L3MBTL1SMN1; SMN2GAA | |
| SCHEMBL7370715 | 0.82 | KMT2A (0.42) | KMT2AL3MBTL1GAAPKMALDH1A1 | |
| SCHEMBL10629236 | 0.82 | GAA (0.55) | KMT2AMEN1L3MBTL1SMN1; SMN2GAA | |
| SCHEMBL6790329 | 0.81 | SMN1; SMN2 (0.59) | KMT2AMEN1L3MBTL1SMN1; SMN2GAA | |
| SCHEMBL8608392 | 0.81 | KMT2A (0.54) | KMT2AMEN1L3MBTL1SMN1; SMN2GAA | |
| SCHEMBL7412108 | 0.78 | POLB (0.55) | KMT2AMEN1L3MBTL1GAAHDAC8 | |
| SCHEMBL5115089 | 0.77 | GAA (0.52) | SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL92506 | 0.76 | L3MBTL1 (0.63) | L3MBTL1SMN1; SMN2GAAALDH1A1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880512-A1 | NOVEL AROMATIC PIPERAZINES DERIVED FROM SUBSTITUTED CYCLOAZANES, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF AS DRUGS | PIERRE FABRE MEDICAMENT (FR) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028141-A1 | NOVEL AROMATIC PIPERAZINES DERIVED FROM SUBSTITUTED CYCLOAZANES, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF AS DRUGS | PIERRE FABRE MEDICAMENT (FR) | 1997-08-07 | — | — | WO | disclosed |