SCHEMBL8669447

SCHEMBL8669447

FC(F)(F)c1cccc(Oc2cc(Br)nc(OCc3ccccc3)n2)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.45
MRGPRX4 Q96LA9 1/20 0.45
ALDH1A1 P00352 1/20 0.45
POLB P06746 1/20 0.45
LRRK2 Q5S007 1/20 0.43
NR4A2 P43354 2/20 0.42
LOX P28300 1/20 0.41
LOXL2 Q9Y4K0 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
GAA P10253 1/20 0.41
MAOB P27338 4/20 0.41
ABCG2 Q9UNQ0 1/20 0.41
MAPT P10636 1/20 0.41
PPARG P37231 1/20 0.40
PPARA Q07869 1/20 0.40
TEAD1 P28347 1/20 0.40
ADORA2A P29274 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8565553 0.91 MRGPRX4 (0.45) L3MBTL1MRGPRX4ALDH1A1POLBLRRK2
SCHEMBL8664724 0.89 ALDH1A1 (0.46) L3MBTL1MRGPRX4ALDH1A1POLBNR4A2
SCHEMBL8669456 0.87 L3MBTL1 (0.46) L3MBTL1MRGPRX4ALDH1A1POLBLRRK2
SCHEMBL8669825 0.86 SMN1; SMN2 (0.51) L3MBTL1MRGPRX4ALDH1A1POLBLRRK2
SCHEMBL8667521 0.86 L3MBTL1 (0.47) L3MBTL1MRGPRX4ALDH1A1POLBLRRK2
SCHEMBL8667133 0.84 L3MBTL1 (0.42) L3MBTL1MRGPRX4ALDH1A1POLBLRRK2
SCHEMBL8664997 0.83 L3MBTL1 (0.44) L3MBTL1MRGPRX4ALDH1A1POLBLRRK2
SCHEMBL8667049 0.82 L3MBTL1 (0.41) L3MBTL1MRGPRX4ALDH1A1POLBLRRK2
SCHEMBL8508415 0.82 MAPT (0.52) L3MBTL1MRGPRX4ALDH1A1POLBLRRK2
SCHEMBL8773242 0.79 MAOB (0.48) L3MBTL1MRGPRX4ALDH1A1POLBNR4A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5723412-A HERBICIDES KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1998-03-03 US disclosed
EP-0694538-A2 2-benzyloxy-4-phenoxypyrimidine derivative, processes for producing the derivative and herbicidal composition containing the derivative KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1996-01-31 EP disclosed