SCHEMBL8669449

SCHEMBL8669449

FC(F)(F)c1c(Br)ccc(Oc2ccncn2)c1OCc1ccccc1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.34
ALDH1A1 P00352 1/20 0.34
HTT P42858 1/20 0.34
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
ABCB1 P08183 1/20 0.33
LRRK2 Q5S007 1/20 0.32
THRA P10827 2/20 0.32
THRB P10828 2/20 0.32
MAPK14 Q16539 3/20 0.32
BRAF P15056 1/20 0.32
KDR P35968 1/20 0.32
TNNI3K Q59H18 1/20 0.32
GRM2 Q14416 1/20 0.32
MAPT P10636 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
PTGER1 P34995 1/20 0.32
F2 P00734 1/20 0.31
KCNH2 Q12809 1/20 0.31
GRIN2B Q13224 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8669830 0.87 PTPN1 (0.38) ALDH1A1MEN1KMT2AABCB1LRRK2
SCHEMBL8669457 0.87 ABCB1 (0.33) ABCB1LRRK2MAPK14BRAFKDR
SCHEMBL8667523 0.87 EGFR (0.36) ALDH1A1MEN1KMT2AABCB1LRRK2
SCHEMBL8664727 0.87 LMNA (0.38) SMN1; SMN2ALDH1A1HTTMEN1KMT2A
SCHEMBL8667134 0.84 PPARG (0.34) ALDH1A1MEN1KMT2AABCB1LRRK2
SCHEMBL8665000 0.83 BCHE (0.33) ABCB1LRRK2MAPK14BRAFKDR
SCHEMBL8667055 0.82 PPARG (0.33) ALDH1A1MEN1KMT2AABCB1LRRK2
SCHEMBL8951615 0.74 ABCB1 (0.50) ALDH1A1MEN1KMT2AABCB1MAPK14
SCHEMBL8669996 0.73 L3MBTL1 (0.33) MAPK14BRAFKDRTNNI3KMAPT
SCHEMBL2893555 0.73 MAPK14 (0.43) SMN1; SMN2MEN1KMT2ATHRATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5723412-A HERBICIDES KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1998-03-03 US disclosed