Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 14/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21722656 | 0.78 | GRIN2D (0.41) | NLRP3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL29575133 | 0.78 | GRIN2D (0.41) | NLRP3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL29573999 | 0.78 | GRIN2D (0.43) | NLRP3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL21722642 | 0.78 | GRIN2D (0.43) | NLRP3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL23033128 | 0.76 | GRIN2D (0.41) | NLRP3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL29284835 | 0.76 | GRIN2D (0.41) | NLRP3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8667957 | 0.74 | MAPT (0.36) | NLRP3KDM4EMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL11181508 | 0.73 | GRIN2D (0.39) | NLRP3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL30951209 | 0.73 | NLRP3 (0.41) | NLRP3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL29285003 | 0.73 | NLRP3 (0.41) | NLRP3GRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5721234-A | TREATING CONVULSIONS, ANXIETY, CEREBRAL HYPOXIA/ISCHEMIA, PARKINSON*S DISEASE | WARNER-LAMBERT COMPANY (US) | 1998-02-24 | — | — | US | disclosed |
| WO-1998005651-A1 | NOVEL GLUTAMATE RECEPTOR ANTAGONISTS: FUSED CYCLOALKYL QUINOXALINEDIONES | WARNER-LAMBERT COMPANY (US) | 1998-02-12 | — | — | WO | disclosed |
| WO-1996017832-A1 | NOVEL GLUTAMATE RECEPTOR ANTAGONISTS: FUSED CYCLOALKYLQUINOXALINEDIONES | WARNER-LAMBERT COMPANY (US) | 1996-06-13 | — | — | WO | disclosed |