Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4D | Q6B0I6 | 4/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.33 |
| ▸ | CKS1B | P61024 | 1/20 | 0.33 |
| ▸ | SKP1 | P63208 | 1/20 | 0.33 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8484139 | 0.96 | NTRK1 (0.36) | KDM4DRETNTRK1NPY5RCKS1B | |
| SCHEMBL8504386 | 0.94 | NTRK1 (0.34) | KDM4DRETNTRK1DPP4 | |
| SCHEMBL8665212 | 0.88 | CCR3 (0.39) | RET | |
| SCHEMBL8666005 | 0.84 | NPY5R (0.36) | KDM4DRETSYKNPY5RTRPV1 | |
| SCHEMBL8500943 | 0.81 | CCR3 (0.36) | RET | |
| SCHEMBL8482320 | 0.81 | NPY5R (0.37) | KDM4DRETNTRK1NPY5RCKS1B | |
| SCHEMBL8503043 | 0.79 | NPY5R (0.33) | KDM4DRETNTRK1DPP4NPY5R | |
| SCHEMBL8504363 | 0.77 | KCNA5 (0.30) | — | |
| SCHEMBL8479385 | 0.76 | DPP4 (0.38) | DPP4NPY5R | |
| SCHEMBL8664869 | 0.73 | SMPD3 (0.38) | CKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5827875-A | PYRROLIDINE DERIVATIVES; ANTIATHEROSCLEROSIS AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-10-27 | — | — | US | disclosed |