Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | METAP2 | P50579 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NEK2 | P51955 | 2/20 | 0.44 |
| ▸ | INSR | P06213 | 2/20 | 0.43 |
| ▸ | IGF1R | P08069 | 2/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8713967 | 0.88 | FGFR1 (0.51) | NOS1MAPTDYRK1AMETAP2KDM4E | |
| SCHEMBL8666607 | 0.84 | MAPK1 (0.51) | NOS1MAPTDYRK1AMETAP2KDM4E | |
| SCHEMBL17584956 | 0.78 | NOS1 (0.58) | NOS1MAPTDYRK1AMETAP2KDM4E | |
| SCHEMBL29569662 | 0.78 | NOS1 (0.53) | NOS1MAPTDYRK1AMETAP2KDM4E | |
| SCHEMBL578417 | 0.78 | NOS1 (0.53) | NOS1MAPTDYRK1AMETAP2KDM4E | |
| SCHEMBL3803624 | 0.77 | MAPT (0.50) | NOS1MAPTDYRK1AMETAP2KDM4E | |
| SCHEMBL8669605 | 0.77 | NOS1 (0.57) | NOS1MAPTDYRK1AMETAP2KDM4E | |
| SCHEMBL13550141 | 0.74 | MAPT (0.53) | NOS1MAPTDYRK1AMETAP2KDM4E | |
| SCHEMBL20721588 | 0.74 | NOS1 (0.53) | NOS1MAPTDYRK1AMETAP2KDM4E | |
| SCHEMBL20721589 | 0.74 | MAPT (0.53) | NOS1MAPTDYRK1AMETAP2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811422-A | USEFUL FOR TREATING VIRAL INFECTIONS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-09-22 | — | — | US | disclosed |
| US-5610294-A | VIRAL TREATMENT | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-03-11 | — | — | US | disclosed |
| EP-0686151-A1 | SUBSTITUTED CYCLIC CARBONYLS AND DERIVATIVES THEREOF USEFUL AS RETROVIRAL PROTEASE INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-12-13 | — | — | EP | disclosed |