Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 3/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NOS1 | P29475 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | METAP2 | P50579 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | INSR | P06213 | 2/20 | 0.41 |
| ▸ | IGF1R | P08069 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8669601 | 0.88 | NOS1 (0.46) | FGFR1HSP90AA1IDO1CDK2DYRK1A | |
| SCHEMBL7072379 | 0.78 | FGFR1 (0.57) | FGFR1HSP90AA1IDO1CDK2DYRK1A | |
| SCHEMBL8666607 | 0.75 | MAPK1 (0.51) | DYRK1AMAPTNOS1KDM4EMETAP2 | |
| SCHEMBL3803624 | 0.75 | MAPT (0.50) | FGFR1HSP90AA1IDO1CDK2DYRK1A | |
| SCHEMBL8669605 | 0.75 | NOS1 (0.57) | FGFR1HSP90AA1IDO1CDK2DYRK1A | |
| SCHEMBL8710672 | 0.73 | CYP1A2 (0.50) | KMT2ARAB9A | |
| SCHEMBL879376 | 0.72 | NOS1 (0.53) | FGFR1HSP90AA1IDO1CDK2DYRK1A | |
| SCHEMBL7132606 | 0.72 | NOS1 (0.58) | FGFR1HSP90AA1IDO1CDK2DYRK1A | |
| SCHEMBL20721589 | 0.72 | MAPT (0.53) | FGFR1HSP90AA1IDO1CDK2DYRK1A | |
| SCHEMBL91332 | 0.72 | MAPT (0.60) | FGFR1HSP90AA1IDO1CDK2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5763469-A | Substituted cyclic ureas and derivatives thereof useful as retroviral protease inhibitors | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-06-09 | — | — | US | disclosed |