Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CPA3 | P15088 | 2/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CPA1 | P15085 | 3/20 | 0.39 |
| ▸ | CPB1 | P15086 | 1/20 | 0.39 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7163448 | 1.00 | SMN1; SMN2 (0.48) | SMN1; SMN2MMP8FKBP1ACYP1A2CPA3 | |
| SCHEMBL9264405 | 0.90 | SMN1; SMN2 (0.41) | SMN1; SMN2MMP8FKBP1AMEN1KMT2A | |
| SCHEMBL9253331 | 0.90 | SMN1; SMN2 (0.41) | SMN1; SMN2MMP8FKBP1AMEN1KMT2A | |
| SCHEMBL9262743 | 0.89 | MMP8 (0.44) | SMN1; SMN2MMP8MEN1KMT2AALDH1A1 | |
| SCHEMBL9261571 | 0.88 | SMN1; SMN2 (0.44) | SMN1; SMN2MMP8FKBP1AMEN1KMT2A | |
| SCHEMBL9285930 | 0.88 | MMP8 (0.43) | SMN1; SMN2MMP8MEN1KMT2AALDH1A1 | |
| SCHEMBL9260415 | 0.87 | HSD17B10 (0.50) | CYP1A2CPA3FOLH1CPA1CPB1 | |
| SCHEMBL9287474 | 0.87 | HSD17B10 (0.50) | CYP1A2CPA3FOLH1CPA1CPB1 | |
| SCHEMBL9260958 | 0.86 | CYP1A2 (0.42) | CYP1A2CPA3FOLH1CPA1CPB1 | |
| SCHEMBL9262360 | 0.85 | CYP1A2 (0.41) | CYP1A2CPA3FOLH1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750649-A | REACTING ACID AND AMINE IN PRESENCE OF CARBODIIMIDE DEHYDRATING AGENT AND N-HYDROXY COMPOUND; PEPTIDES | HOFFMANN-LA ROCHE INC. (US) | 1998-05-12 | — | — | US | disclosed |
| US-5393875-A | Hypotensive, cardiotonic and antiischemic agents | HOFFMANN-LA ROCHE INC. (US) | 1995-02-28 | — | — | US | disclosed |