SCHEMBL8670660

SCHEMBL8670660

O=C(O)CCCCCNC(=O)c1cccc(O)c1O

nearest known ligand 0.82

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 5/20 0.82
MAPK1 P28482 1/20 0.59
NAAA Q02083 1/20 0.56
ALDH1A1 P00352 2/20 0.55
LMNA P02545 2/20 0.55
NPC1 O15118 1/20 0.52
MAPT P10636 1/20 0.52
HPGD P15428 1/20 0.52
TSHR P16473 1/20 0.52
HTT P42858 1/20 0.52
NPSR1 Q6W5P4 1/20 0.52
HSD17B10 Q99714 1/20 0.52
NLRP1 Q9C000 1/20 0.52
CYP1A2 P05177 1/20 0.52
CYP2C9 P11712 1/20 0.52
CYP2C19 P33261 1/20 0.52
NR1H4 Q96RI1 2/20 0.51
PPARG P37231 2/20 0.49
HDAC6 Q9UBN7 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5657646 1.00 ALOX5 (0.82) ALOX5MAPK1NAAAALDH1A1LMNA
SCHEMBL21579680 0.98 ALOX5 (0.79) ALOX5MAPK1NAAAALDH1A1LMNA
SCHEMBL24402691 0.91 ALOX5 (1.00) ALOX5NAAAALDH1A1NPC1MAPT
SCHEMBL30686689 0.91 ALOX5 (1.00) ALOX5NAAAALDH1A1NPC1MAPT
SCHEMBL31473032 0.91 ALOX5 (1.00) ALOX5NAAAALDH1A1NPC1MAPT
SCHEMBL14760836 0.91 ALOX5 (1.00) ALOX5NAAAALDH1A1NPC1MAPT
SCHEMBL664024 0.89 NAAA (0.70) ALOX5MAPK1NAAAALDH1A1LMNA
SCHEMBL14088979 0.89 NAAA (0.70) ALOX5MAPK1NAAAALDH1A1LMNA
SCHEMBL6383063 0.89 NAAA (0.70) ALOX5MAPK1NAAAALDH1A1LMNA
SCHEMBL14088978 0.89 NAAA (0.70) ALOX5MAPK1NAAAALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4409240-A ANTICOAGULANTS, ANTIINFLAMMATORY AGENTS, HYPOTENSIVE AGENTS, BRONCHODILATOR, AND ANTIARTHRITIC AGENTS KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1983-10-11 US claimed
US-5854250-A N-benzoylamino acid derivatives, pharmaceutical compositions containing them and process of preparing same GYOGYSZERKUTATO INTEZET KFT (HU) 1998-12-29 US disclosed
US-5705529-A ANTIISCHEMIC AGENTS, ANTIINFLAMMATORY AGENTS, AGING RESISTANCE, ATHERIOSCLEROSIS, NERVOUS SYSTEM DISORDERS GYOGYSZERKUTATO INTEZET KFT (HK) 1998-01-06 US disclosed
EP-0576941-B1 N-benzoylamino acid derivatives, pharmaceutical compositions containing them and process for preparing same NISSHIN FLOUR MILLING CO (JP) 1997-09-03 EP disclosed
EP-0576941-A1 N-benzoylamino acid derivatives, pharmaceutical compositions containing them and process for preparing same NISSHIN FLOUR MILLING CO., LTD. (JP) 1994-01-05 EP disclosed
EP-0059108-B1 DERIVATIVES OF DIHYDROXYBENZOIC ACID KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1985-08-14 EP disclosed
US-4409240-A ANTICOAGULANTS, ANTIINFLAMMATORY AGENTS, HYPOTENSIVE AGENTS, BRONCHODILATOR, AND ANTIARTHRITIC AGENTS KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1983-10-11 US disclosed
EP-0059108-A1 Derivatives of dihydroxybenzoic acid KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1982-09-01 EP disclosed