Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | L3MBTL3 | Q96JM7 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 2/20 | 0.35 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8672548 | 0.79 | SLC18A3 (0.52) | NPC1SLC18A3HTR1DHTR1AHTR7 | |
| SCHEMBL30567319 | 0.75 | RXFP1 (0.51) | NPC1RXFP1TP53CA1CA2 | |
| SCHEMBL6674584 | 0.75 | RXFP1 (0.51) | NPC1RXFP1TP53CA1CA2 | |
| SCHEMBL2952459 | 0.75 | RXFP1 (0.51) | NPC1RXFP1TP53CA1CA2 | |
| SCHEMBL8668624 | 0.75 | RXFP1 (0.40) | NPC1SLC18A3RXFP1CYP1A2CA1 | |
| SCHEMBL8673705 | 0.74 | MAPT (0.39) | NPC1L3MBTL3L3MBTL1 | |
| SCHEMBL4199477 | 0.73 | CYP1A2 (0.54) | CYP1A2HTR1D | |
| SCHEMBL4970280 | 0.73 | CYP1A2 (0.54) | CYP1A2HTR1D | |
| SCHEMBL6785452 | 0.71 | RXFP1 (0.44) | NPC1RXFP1CA1CA2CA9 | |
| SCHEMBL7983593 | 0.70 | RXFP1 (0.43) | RXFP1CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5721234-A | TREATING CONVULSIONS, ANXIETY, CEREBRAL HYPOXIA/ISCHEMIA, PARKINSON*S DISEASE | WARNER-LAMBERT COMPANY (US) | 1998-02-24 | — | — | US | disclosed |
| WO-1996017832-A1 | NOVEL GLUTAMATE RECEPTOR ANTAGONISTS: FUSED CYCLOALKYLQUINOXALINEDIONES | WARNER-LAMBERT COMPANY (US) | 1996-06-13 | — | — | WO | disclosed |