Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD1 | P21728 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4199477 | 1.00 | CYP1A2 (0.54) | CYP1A2ADRA1ASIGMAR1HTR1DHIF1A | |
| Hydrochloric Acid SCHEMBL9341275 | 0.87 | CYP1A2 (0.50) | CYP1A2ADRA1ASIGMAR1CYP19A1DRD2 | |
| SCHEMBL4202362 | 0.83 | ADRA1A (0.48) | CYP1A2ADRA1ASIGMAR1HTR1DHIF1A | |
| SCHEMBL4215401 | 0.77 | CHRM2 (0.55) | SIGMAR1HTR1DDRD2HTR2CHTR2B | |
| SCHEMBL4216852 | 0.77 | HTR1A (0.36) | CYP1A2ADRA1ASIGMAR1HIF1AEPAS1 | |
| SCHEMBL8677765 | 0.76 | SIGMAR1 (0.54) | SIGMAR1HTR1DDRD2HTR2CHTR2B | |
| SCHEMBL11393302 | 0.76 | SIGMAR1 (0.54) | SIGMAR1HTR1DDRD2HTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL7935858 | 0.75 | SIGMAR1 (0.53) | SIGMAR1HTR1DDRD2HTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL7933015 | 0.75 | SIGMAR1 (0.53) | SIGMAR1HTR1DDRD2HTR2CHTR2B | |
| SCHEMBL4217393 | 0.75 | ADRA1A (0.78) | CYP1A2ADRA1ACYP19A1KDM4EDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888517-A1 | NOVEL 8-SULFONYLAMINO-3 AMINOSUBSTITUTED CHROMAN OR TETRAHYDRONAPHTALENE DERIVATIVES MODULATING THE 5HT6 RECEPTOR | AstraZeneca AB (SE) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006126939-A1 | NOVEL 8-SULFONYLAMINO-3 AMINOSUBSTITUTED CHROMAN OR TETRAHYDRONAPHTALENE DERIVATIVES MODULATING THE 5HT6 RECEPTOR | ASTRAZENECA AB (SE) | 2006-11-30 | — | — | WO | disclosed |