Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.45 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | CBLB | Q13191 | 6/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TGM2 | P21980 | 2/20 | 0.32 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.32 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.32 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.32 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25211286 | 0.98 | ZDHHC20 (0.46) | ZDHHC20ZDHHC2KMT2AATMCBLB | |
| Hydrochloric Acid SCHEMBL8674800 | 0.97 | ZDHHC20 (0.47) | ZDHHC20ZDHHC2KMT2AATMCBLB | |
| SCHEMBL16356899 | 0.86 | ZDHHC20 (0.49) | ZDHHC20ZDHHC2KMT2AATMCBLB | |
| SCHEMBL23565829 | 0.83 | KMT2A (0.41) | ZDHHC20ZDHHC2KMT2AATMCBLB | |
| SCHEMBL23542769 | 0.83 | ZDHHC20 (0.44) | ZDHHC20ZDHHC2KMT2AATMCBLB | |
| SCHEMBL23201936 | 0.82 | KMT2A (0.40) | ZDHHC20ZDHHC2KMT2AATMCBLB | |
| SCHEMBL11409313 | 0.82 | KMT2A (0.40) | ZDHHC20ZDHHC2KMT2AATMCBLB | |
| SCHEMBL31509638 | 0.82 | ZDHHC20 (0.58) | ZDHHC20ZDHHC2KMT2AATMCBLB | |
| SCHEMBL25625947 | 0.81 | KMT2A (0.40) | ZDHHC20ZDHHC2KMT2AATMCBLB | |
| SCHEMBL14652902 | 0.81 | ZDHHC20 (0.56) | ZDHHC20ZDHHC2KMT2AATMCBLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0735186-A2 | Additive for papermaking and process for papermaking | JAPAN PMC CORPORATION (JP) | 1996-10-02 | — | — | EP | claimed |
| US-9834022-B2 | Thermal recording material | MITSUBISHI PAPER MILLS LIMITED (JP) | 2017-12-05 | — | — | US | disclosed |
| US-20160332469-A1 | THERMAL RECORDING MATERIAL | MITSUBISHI PAPER MILLS LIMITED (JP) | 2016-11-17 | — | — | US | disclosed |
| US-5756646-A | HYDROLYZED ACRYLAMIDE RESIN OBTAINED BY POLYMERIZATION IN PRESENCE OF UREA COMPOUND | JAPAN PMC CORPORATION (JP) | 1998-05-26 | — | — | US | disclosed |
| US-5698627-A | AN AQUEOUS SOLUTION OF A COPOLYMER OF AN ACRYLAMIDE, A VINYL COMPOUND HAVING A CATIONIC GROUP AND ANOTHER UNSATURATED COMPOUND PREPARED IN THE PRESENCE OF A POLYHYDROXY COMPOUND; FREENESS; RETENTION; HIGH STRENGTH | JAPAN PMC CORPORATION (JP) | 1997-12-16 | — | — | US | disclosed |
| EP-0735186-A2 | Additive for papermaking and process for papermaking | JAPAN PMC CORPORATION (JP) | 1996-10-02 | — | — | EP | disclosed |
| EP-0732448-A2 | Agent for improving surface quality of paper | JAPAN PMC CORPORATION (JP) | 1996-09-18 | — | — | EP | disclosed |
| US-5115065-A | Bisquaternary ammonium (meth)acrylamide polymer for increased paper strength and filler retention | DIC-HERCULES CHEMICALS, INC. (JP) | 1992-05-19 | — | — | US | disclosed |