Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.64 |
| ▸ | LMNA | P02545 | 6/20 | 0.64 |
| ▸ | HTT | P42858 | 5/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.61 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | STAT3 | P40763 | 1/20 | 0.56 |
| ▸ | TNF | P01375 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | PDE5A | O76074 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7995805 | 0.87 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNAHTTTSHRNPSR1 | |
| SCHEMBL30826274 | 0.80 | CYP11B1 (0.77) | SMN1; SMN2LMNAHTTCYP11B1CYP11B2 | |
| SCHEMBL4142913 | 0.80 | CYP11B1 (0.77) | SMN1; SMN2LMNAHTTCYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL31253891 | 0.78 | CYP11B1 (0.75) | SMN1; SMN2LMNAHTTCYP11B1CYP11B2 | |
| Bromide SCHEMBL31253900 | 0.78 | CYP11B1 (0.75) | SMN1; SMN2LMNAHTTCYP11B1CYP11B2 | |
| SCHEMBL16756283 | 0.78 | CYP11B1 (0.57) | SMN1; SMN2LMNAHTTTSHRNPSR1 | |
| SCHEMBL7994263 | 0.76 | LMNA (0.53) | SMN1; SMN2LMNAHTTTSHRNPSR1 | |
| SCHEMBL20715592 | 0.75 | CYP11B1 (0.66) | SMN1; SMN2LMNAHTTTSHRNPSR1 | |
| SCHEMBL20547652 | 0.75 | CYP11B1 (0.66) | SMN1; SMN2LMNAHTTTSHRNPSR1 | |
| SCHEMBL30099869 | 0.75 | CYP11B1 (0.66) | SMN1; SMN2LMNAHTTTSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5801180-A | ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | EISAI CO., LTD. (JP) | 1998-09-01 | — | — | US | disclosed |
| US-5693652-A | Benzimidazoles for ischemic heart conditions | EISAI CO., LTD. (JP) | 1997-12-02 | — | — | US | disclosed |
| US-5576322-A | Anti-ischemic 2,4-diaminoquinazolines | EISAI CO., LTD. (JP) | 1996-11-19 | — | — | US | disclosed |
| EP-0607439-A1 | NITROGENOUS HETEROCYCLIC COMPOUND | Eisai Co., Ltd. (JP) | 1994-07-27 | — | — | EP | disclosed |