Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 3/20 | 0.39 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.39 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GALR3 | O60755 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.33 |
| ▸ | CPT2 | P23786 | 1/20 | 0.33 |
| ▸ | CPT1A | P50416 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1276371 | 1.00 | MAPT (0.45) | MAPTBLMSMN1; SMN2GALR3POLB | |
| SCHEMBL6153646 | 0.98 | MAPT (0.41) | MAPTBLMSMN1; SMN2GALR3POLB | |
| SCHEMBL77665 | 0.98 | MAPT (0.41) | MAPTBLMSMN1; SMN2GALR3POLB | |
| Water SCHEMBL16322375 | 0.95 | MAPT (0.40) | MAPTBLMSMN1; SMN2GALR3POLB | |
| Bromide SCHEMBL7172545 | 0.95 | MAPT (0.40) | MAPTBLMSMN1; SMN2GALR3POLB | |
| Bromide SCHEMBL9233901 | 0.95 | MAPT (0.40) | MAPTBLMSMN1; SMN2GALR3POLB | |
| SCHEMBL4318608 | 0.95 | MAPT (0.40) | MAPTBLMSMN1; SMN2GALR3POLB | |
| Iodide SCHEMBL400576 | 0.95 | MAPT (0.40) | MAPTBLMSMN1; SMN2GALR3POLB | |
| Perchlorate SCHEMBL9097182 | 0.90 | SLC22A16 (0.41) | MAPTBLMSMN1; SMN2GALR3POLB | |
| SCHEMBL8055941 | 0.76 | MAPT (0.39) | MAPTBLMSMN1; SMN2GALR3SLC22A16 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726323-A | COMPOUNDS USEFUL FOR ALLEVIATING MEMORY DYSFUNCTIONS | HOECHST MARION ROUSSEL, INC. | 1998-03-10 | — | — | US | disclosed |
| US-5663190-A | INHIBITORS OF ACETYLCHOLINESTERASE, TREATMENT OF ALZHEIMER*S DISEASE | HOECHST MARION ROUSSEL, INC. (US) | 1997-09-02 | — | — | US | disclosed |
| EP-0420140-B1 | N-Aminocarbamates related to physostigmine, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1997-08-13 | — | — | EP | disclosed |
| US-5639892-A | ANTIDEPRESSANTS, ALZHEIMER'S DISEASE | HOECHST-MARION-ROUSSEL, INC. (US) | 1997-06-17 | — | — | US | disclosed |
| US-5621114-A | REACTING A THIO OR PHENOL COMPOUND WITH 1,1-CARBONYLIMIDAZOLE OR 1,1-THIOCARBONYLDIIMIDAZOLE, REACTING THE INTERMEDIATE WITH SECONDARY AMINE COMPOUND; USEFUL AS ANALGESIC AND MEMORY ENHANCING AGENT | HOECHST MARION ROUSSEL, INC. (US) | 1997-04-15 | — | — | US | disclosed |
| US-5591864-A | CHEMICAL INTERMEDIATES FOR COMPOUNDS WHICH ALLEVIATE MEMORY DYSFUNCITONS | HOECHST MARION ROUSSEL, INC. (US) | 1997-01-07 | — | — | US | disclosed |
| EP-0430201-B1 | Aminocarbonylcarbamates related to physostigmine, a process for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1996-09-18 | — | — | EP | disclosed |
| US-5550254-A | REACTING CARBOXYLIC ACID WITH CARBONYLDIIMIDAZOLE OR THIOCARBONYLDIIMIDAZOLE, ADDING PHENOL OR THIOPHENOL COMPOUND | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1996-08-27 | — | — | US | disclosed |
| US-5550253-A | REACTING PHENOL OR THIOPHENOL DERIVATIVE WITH LOWER ALKYL P-TOLUENESULFONATE, OPTIONALLY REDUCING NITRO GROUPS TO AMINO GROUPS AND ACYLATING OR ALKYLATING THEM | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1996-08-27 | — | — | US | disclosed |
| US-5547977-A | Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8(and 1,3A,8)-di (and Tri) methylpyrrolo (2,3-B) indoles | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1996-08-20 | — | — | US | disclosed |
| US-5077289-A | Cholinergic function enhancers | HOECHST ROUSSEL PHARMACEUTICALS INC. (US) | 1991-12-31 | — | — | US | disclosed |
| EP-0440145-A1 | Hexahydropyrrolo[2,3-b]indole carbamates,-ureas,-amides and related compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-08-07 | — | — | EP | disclosed |
| EP-0430201-A2 | Aminocarbonylcarbamates related to physostigmine, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-06-05 | — | — | EP | disclosed |
| US-5010083-A | Cognition activator; Alzheimer*s disease | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1991-04-23 | — | — | US | disclosed |
| EP-0420140-A2 | N-Aminocarbamates related to physostigmine, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-04-03 | — | — | EP | disclosed |
| US-4983616-A | Analgesics, cognition activators | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-01-08 | — | — | US | disclosed |
| US-4937341-A | Process for preparing N-aminocarbarbamates related to physostigmine | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-06-26 | — | — | US | disclosed |
| US-4914102-A | ALLEVIATING MEMORY DYSFUNCTIONS CHARACTERIZED BY CHOLINERGIC DEFICIT | HOECHST ROUSSEL PHARMACEUTICALS, INC. (US) | 1990-04-03 | — | — | US | disclosed |
| US-4791107-A | Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-12-13 | — | — | US | disclosed |
| EP-0253372-A2 | 1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indoles, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-01-20 | — | — | EP | disclosed |