Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.53 |
| ▸ | DRD3 | P35462 | 3/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
| ▸ | HTR7 | P34969 | 3/20 | 0.47 |
| ▸ | HTR1D | P28221 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | HTR5A | P47898 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7926395 | 0.99 | DRD2 (0.52) | DRD2DRD3DRD4CHRM3CHRM2 | |
| SCHEMBL8891819 | 0.84 | DRD2 (0.62) | DRD2DRD3DRD4CHRM3CHRM2 | |
| SCHEMBL5585108 | 0.81 | DRD2 (0.80) | DRD2DRD3DRD4HTR1AHTR7 | |
| SCHEMBL7935806 | 0.80 | DRD2 (0.61) | DRD2DRD3DRD4HTR1ACYP1A2 | |
| SCHEMBL3807709 | 0.80 | HTR1A (0.53) | DRD2DRD3DRD4CHRM3HTR1A | |
| SCHEMBL9558513 | 0.80 | DRD2 (0.61) | DRD2DRD3DRD4HTR1ACYP1A2 | |
| SCHEMBL8890551 | 0.79 | DRD2 (0.67) | DRD2DRD3DRD4HTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL7936627 | 0.79 | DRD2 (0.60) | DRD2DRD3DRD4HTR1ACYP1A2 | |
| Hydrochloric Acid SCHEMBL7926385 | 0.79 | HTR1A (0.52) | DRD2DRD3DRD4CHRM3HTR1A | |
| SCHEMBL8894457 | 0.78 | CHRM3 (0.58) | DRD2DRD3DRD4CHRM3CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2785879-B2 | — | — | 1998-08-13 | — | — | JP | claimed |
| EP-0476016-A1 | THERAPEUTICALLY USEFUL 2-AMINOTETRALIN DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 1992-03-25 | — | — | EP | claimed |
| WO-1990015047-A1 | THERAPEUTICALLY USEFUL 2-AMINOTETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1990-12-13 | — | — | WO | claimed |