Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | NPC1 | O15118 | 3/20 | 0.82 |
| ▸ | RAB9A | P51151 | 3/20 | 0.82 |
| ▸ | MAPT | P10636 | 2/20 | 0.82 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.82 |
| ▸ | AGXT | P21549 | 2/20 | 0.61 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.57 |
| ▸ | NCF1 | P14598 | 6/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.54 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15657734 | 1.00 | TDP1 (1.00) | TDP1KDM4EMAPK1NPC1RAB9A | |
| SCHEMBL8674825 | 1.00 | TDP1 (1.00) | TDP1KDM4EMAPK1NPC1RAB9A | |
| SCHEMBL16902851 | 0.93 | TDP1 (0.87) | TDP1KDM4EMAPK1NPC1RAB9A | |
| SCHEMBL8675366 | 0.92 | TDP1 (0.85) | TDP1KDM4EMAPK1NPC1RAB9A | |
| SCHEMBL20110895 | 0.91 | KDM4E (0.82) | TDP1KDM4EMAPK1NPC1RAB9A | |
| SCHEMBL9492894 | 0.91 | KDM4E (0.82) | TDP1KDM4EMAPK1NPC1RAB9A | |
| SCHEMBL13196822 | 0.91 | KDM4E (0.82) | TDP1KDM4EMAPK1NPC1RAB9A | |
| SCHEMBL16021964 | 0.91 | KDM4E (0.82) | TDP1KDM4EMAPK1NPC1RAB9A | |
| SCHEMBL20110893 | 0.91 | TDP1 (0.82) | TDP1KDM4EMAPK1NPC1RAB9A | |
| SCHEMBL16021974 | 0.91 | KDM4E (0.82) | TDP1KDM4EMAPK1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11529354-B2 | Methods and compositions for the treatment of tuberculosis | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2022-12-20 | — | — | US | disclosed |
| US-11529354-B2 | Methods and compositions for the treatment of tuberculosis | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2022-12-20 | — | — | US | disclosed |
| US-20210137932-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF TUBERCULOSIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-05-13 | — | — | US | disclosed |
| US-20210137932-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF TUBERCULOSIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-05-13 | — | — | US | disclosed |
| US-5827796-A | Thermal recording material | FUJI PHOTO FILM CO., LTD. (JP) | 1998-10-27 | — | — | US | disclosed |
| US-4981836-A | Recording material | FUJI PHOTO FILM CO., LTD. (JP) | 1991-01-01 | — | — | US | disclosed |
| US-4855278-A | Heat-sensitive recording material | FUJI PHOTO FILM CO., LTD. (JP) | 1989-08-08 | — | — | US | disclosed |
| US-4835133-A | Recording material | FUJI PHOTO FILM CO., LTD. (JP) | 1989-05-30 | — | — | US | disclosed |
| US-4115216-A | QUARTERNARY AMMONIUM COMPOUNDS | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-09-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11529354-B2 | Methods and compositions for the treatment of tuberculosis | IFNG, FNTB, TYMS | TDP1 3603/4885KDM4E 4321/4885MAPK1 4411/4885 |
| US-20210137932-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF TUBERCULOSIS | IFNG, FNTB, TYMS | TDP1 3603/4885KDM4E 4321/4885MAPK1 4411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.