SCHEMBL8674281

SCHEMBL8674281

O=C(O)/C(CC1CCC2OC2C1)=C(/CC1CCC2OC2C1)C(=O)O

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TFPI2 P48307 5/20 0.39
KDM4E B2RXH2 1/20 0.39
GMNN O75496 1/20 0.39
LMNA P02545 1/20 0.39
PMP22 Q01453 1/20 0.39
TP53 P04637 1/20 0.39
TSHR P16473 1/20 0.39
NFKB1 P19838 1/20 0.39
THPO P40225 1/20 0.39
PPM1B O75688 4/20 0.32
PTPN1 P18031 3/20 0.32
PPP1CC P36873 3/20 0.32
PPP5C P53041 2/20 0.30
PPP2CA P67775 1/20 0.30
NPY4R P50391 1/20 0.30
ALDH1A1 P00352 1/20 0.30
POLB P06746 1/20 0.30
MAPT P10636 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8674284 1.00 TFPI2 (0.39) TFPI2KDM4EGMNNLMNAPMP22
SCHEMBL15069506 0.85 TFPI2 (0.39) TFPI2KDM4EGMNNLMNAPMP22
SCHEMBL754254 0.84 ALDH1A1 (0.43) TFPI2KDM4EGMNNLMNAPMP22
SCHEMBL4663418 0.82 TFPI2 (0.38) TFPI2KDM4EGMNNLMNAPMP22
SCHEMBL308407 0.81 TFPI2 (0.36) TFPI2KDM4EGMNNLMNAPMP22
SCHEMBL23174606 0.79 ALDH1A1 (0.40) TFPI2KDM4EGMNNLMNAPMP22
SCHEMBL28496654 0.79 KDM4E (0.34) TFPI2KDM4EGMNNLMNAPMP22
SCHEMBL28586943 0.79 KDM4E (0.34) TFPI2KDM4EGMNNLMNAPMP22
SCHEMBL11056909 0.78 TFPI2 (0.35) TFPI2KDM4EGMNNLMNAPMP22
Bicarbonate SCHEMBL2015874 0.78 TFPI2 (0.43) TFPI2KDM4EGMNNLMNAPMP22

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5543373-A OLEFIN POLYMERIZATION CATALYST HOECHST AG (DE) 1996-08-06 US claimed
US-5777009-A Flame retardant low Tg polyestercarbonate GENERAL ELECTRIC COMPANY (US) 1998-07-07 US disclosed
EP-0838503-A1 Flame retardant composition of polyerstercarbonate, halogenated polycarbonate, potassium diphenylsulfone sulfonate and polytetrafluoroethylene GENERAL ELECTRIC COMPANY (US) 1998-04-29 EP disclosed
US-5741868-A Olefin polymerization process by using a substituted indenyl containing metallocene catalyst HOECHST AKTIENGESELLSCHAFT (DE) 1998-04-21 US disclosed
EP-0311894-B1 Aqueous dispersions, process for their preparation and their application BAYER AG (DE) 1995-11-15 EP disclosed
EP-0563316-B1 POLYOXAZOLIDONES FULLER H B LICENSING FINANC (US) 1995-03-08 EP disclosed
EP-0563316-A1 POLYOXAZOLIDONES. FULLER H B LICENSING FINANC (US) 1993-10-06 EP disclosed
US-5138016-A Using zinc halide catalyst H. B. FULLER COMPANY (US) 1992-08-11 US disclosed
WO-1992011304-A1 NOVEL CATALYST FOR PRODUCTION OF OXAZOLIDINE COMPOUNDS H.B. FULLER LICENSING & FINANCING INC. (US) 1992-07-09 WO disclosed
EP-0311894-A2 Aqueous dispersions, process for their preparation and their application BAYER AG (DE) 1989-04-19 EP disclosed
US-4766158-A CATALYTIC REACTION OF POLYISOCYANATES AND POLYEPOXIDE OLIN CORPORATION (US) 1988-08-23 US disclosed
US-4699931-A REACTING POLYISOCYANATE WITH POLYEPOXIDE-THERMAL STABILITY OLIN CORPORATION (US) 1987-10-13 US disclosed
EP-0060424-B1 SIZE COMPOSITION FOR GLASS FIBRES BAYER AG (DE) 1984-05-09 EP disclosed
EP-0027942-B1 SIZING COMPOSITION FOR GLASS FIBRES, GLASS FIBRES SIZED THEREWITH AND PROCESS FOR THEIR PREPARATION, AS WELL AS GLASS FIBRE COMPOSITES BAYER AG (DE) 1983-03-16 EP disclosed
EP-0060424-A2 Size composition for glass fibres BAYER AG (DE) 1982-09-22 EP disclosed
EP-0027942-A1 Sizing composition for glass fibres, glass fibres sized therewith and process for their preparation, as well as glass fibre composites BAYER AG (DE) 1981-05-06 EP disclosed
US-4066628-A REACTING ORGANIC ISOCYANATE WITH AN EPOXIDE MITSUBISHI CHEMICAL INDUSTRIES LTD. (JA) 1978-01-03 US disclosed
US-4038338-A NEW POLYEPOXIDE-POLYSILOXANE COMPOUNDS CIBA-GEIGY CORPORATION (US) 1977-07-26 US disclosed