Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TFPI2 | P48307 | 5/20 | 0.43 |
| ▸ | GMNN | O75496 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | THPO | P40225 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | STAT6 | P42226 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PPM1B | O75688 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15770 | 0.89 | — | — | |
| SCHEMBL15980922 | 0.89 | — | — | |
| Formic Acid SCHEMBL2248024 | 0.85 | TFPI2 (0.32) | TFPI2GMNNLMNAPMP22TP53 | |
| SCHEMBL16217683 | 0.84 | — | — | |
| SCHEMBL2800064 | 0.82 | ANPEP (0.44) | TFPI2GMNNLMNAPMP22TP53 | |
| SCHEMBL3548485 | 0.81 | PTGS1 (0.33) | — | |
| SCHEMBL754254 | 0.81 | ALDH1A1 (0.43) | TFPI2GMNNLMNAPMP22TP53 | |
| SCHEMBL15707736 | 0.80 | — | — | |
| SCHEMBL1904180 | 0.78 | CHRM5 (0.32) | — | |
| SCHEMBL4663418 | 0.78 | TFPI2 (0.38) | TFPI2GMNNLMNAPMP22TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6579914-B1 | Coating compositions for optical waveguides and optical waveguides coated therewith | ALCATEL (FR) | 2003-06-17 | — | — | US | claimed |
| JP-2075617-A | — | — | None | — | — | JP | disclosed |
| JP-57018028-A | — | — | None | — | — | JP | disclosed |
| JP-55127424-A | — | — | None | — | — | JP | disclosed |
| CN-111295424-A | Aqueous coating composition and process for forming multi-component composite coatings on substrates | PPG工业俄亥俄公司 | 2020-06-16 | — | — | CN | disclosed |
| CN-111253904-A | High-adhesion UV adhesive and preparation method thereof | 詹志豪 | 2020-06-09 | — | — | CN | disclosed |
| EP-2515875-B1 | POLYMERIZABLE LACTAMIC COPOLYMERS SUITABLE FOR THE FORMATION OF COATINGS ON MICROENCAPSULATED PARTICLES | ISP INVESTMENTS LLC (US) | 2019-03-13 | — | — | EP | disclosed |
| US-10118981-B2 | Lactamic polymer containing an acetoacetate moiety | ISP INVESTMENTS LLC (US) | 2018-11-06 | — | — | US | disclosed |
| US-9757704-B2 | Polymerizable lactamic copolymers suitable for the formation of coatings on microencapsulated particles | ISP INVESTMENTS LLC (US) | 2017-09-12 | — | — | US | disclosed |
| US-20170022313-A1 | LACTAMIC POLYMER CONTAINING AN ACETOACETATE MOIETY | ISP INVESTMENTS LLC (US) | 2017-01-26 | — | — | US | disclosed |
| EP-0964792-B1 | ADHESIVE SYSTEMS FOR A ONE OR MULTI STEP ADHESIVE BINDING METHOD, METHOD FOR ADHESIVE BINDING OF PRINTED MATTER | HENKEL KGAA (DE) | 2002-06-12 | — | — | EP | disclosed |
| US-6294616-B1 | COMPATIBILITY; OPTICAL CLARITY | B. F. GOODRICH COMPANY | 2001-09-25 | — | — | US | disclosed |
| JP-2000086967-A | RESIN COMPOSITION FOR COATING | TORAY IND INC | 2000-03-28 | — | — | JP | disclosed |
| EP-0964792-A1 | ADHESIVE SYSTEMS FOR A ONE OR MULTI STEP ADHESIVE BINDING METHOD, METHOD FOR ADHESIVE BINDING OF PRINTED MATTER | Henkel Kommanditgesellschaft auf Aktien (DE) | 1999-12-22 | — | — | EP | disclosed |
| WO-1998040225-A1 | ADHESIVE SYSTEMS FOR A ONE OR MULTI STEP ADHESIVE BINDING METHOD, METHOD FOR ADHESIVE BINDING OF PRINTED MATTER | HENKEL KOMMANDITGESELLSCHAFT AUF ATKIEN (DE) | 1998-09-17 | — | — | WO | disclosed |
| EP-0828769-A1 | BLENDS AND ALLOYS OF POLYCYCLIC POLYMERS | THE B.F. GOODRICH COMPANY (US) | 1998-03-18 | — | — | EP | disclosed |
| WO-1996037528-A1 | BLENDS AND ALLOYS OF POLYCYCLIC POLYMERS | THE B.F. GOODRICH COMPANY (US) | 1996-11-28 | — | — | WO | disclosed |
| JP-H0275617-A | RESIN COMPOSITION FOR OPTICAL MOLDING | ASAHI DENKA KOGYO KK | 1990-03-15 | — | — | JP | disclosed |
| JP-S5718028-A | MAGNETIC RECORDING MEDIUM | MATSUSHITA ELECTRIC IND CO LTD | 1982-01-29 | — | — | JP | disclosed |
| JP-S55127424-A | CURABLE RESIN COMPOSITION | TORAY IND INC | 1980-10-02 | — | — | JP | disclosed |