SCHEMBL867435

SCHEMBL867435

COc1cc(/C=C/C(=O)C(O)C(c2cc(N)cc(N)c2)C(O)C(=O)/C=C/c2ccc(OC(=O)c3ccc(OCC(F)(F)F)cc3)c(OC)c2)ccc1OC(=O)c1ccc(OCC(F)(F)F)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.45
MEN1 O00255 5/20 0.45
KDM4E B2RXH2 3/20 0.45
POLB P06746 1/20 0.45
MAPT P10636 2/20 0.43
LMNA P02545 2/20 0.43
ALDH1A1 P00352 4/20 0.42
CA1 P00915 2/20 0.42
CA2 P00918 2/20 0.42
HPGD P15428 2/20 0.41
GAA P10253 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
TNFRSF1A P19438 1/20 0.40
CA12 O43570 1/20 0.39
CA4 P22748 1/20 0.39
CA9 Q16790 1/20 0.39
TOP2A P11388 2/20 0.39
ABCG2 Q9UNQ0 2/20 0.39
SYK P43405 1/20 0.38
VCP P55072 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL866835 0.92 KDM4E (0.43) KMT2AMEN1KDM4EPOLBMAPT
SCHEMBL866761 0.91 KDM4E (0.43) KMT2AMEN1KDM4EPOLBMAPT
SCHEMBL1565208 0.90 KMT2A (0.47) KMT2AMEN1KDM4EPOLBMAPT
SCHEMBL865380 0.90 MEN1 (0.43) KMT2AMEN1KDM4EPOLBMAPT
SCHEMBL866467 0.90 KDM4E (0.44) KMT2AMEN1KDM4EPOLBMAPT
SCHEMBL867344 0.88 MAPT (0.42) KMT2AMEN1KDM4EPOLBMAPT
SCHEMBL866830 0.88 MAOB (0.39) KDM4EMAPTLMNAALDH1A1SMN1; SMN2
SCHEMBL866547 0.88 MAOB (0.39) KDM4EMAPTLMNAALDH1A1SMN1; SMN2
SCHEMBL866614 0.87 KMT2A (0.45) KMT2AMEN1KDM4EPOLBMAPT
SCHEMBL865623 0.84 CA1 (0.46) KMT2AMEN1KDM4EPOLBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107438653-B Photoalignment composition 罗利克有限公司 2022-01-07 CN disclosed
CN-113652167-A Photoalignment composition 罗利克有限公司 2021-11-16 CN disclosed
US-10557085-B2 Photoalignment composition ROLIC AG (CH) 2020-02-11 US disclosed
US-20180079961-A1 PHOTOALIGNMENT COMPOSITION ROLIC AG (CH) 2018-03-22 US disclosed
US-20170362381-A1 THERMALLY STABLE ALIGNMENT MATERIALS ROLIC AG (CH) 2017-12-21 US disclosed
EP-1966119-B1 PHOTOCROSSLINKABLE MATERIALS ROLIC AG (CH) 2016-10-19 EP disclosed
US-8329823-B2 Photocrosslinkable materials ROLIC AG (CH) 2012-12-11 US disclosed
US-8173749-B2 Photocrosslinkable materials ROLIC AG (CH) 2012-05-08 US disclosed
US-20120076952-A1 PHOTOCROSSLINKABLE MATERIALS ROLIC AG (CH) 2012-03-29 US disclosed
US-20080293888-A1 Photocrosslinkable Materials ROLIC AG (CH) 2008-11-27 US disclosed
EP-1975687-A1 Method of uniform and defect free liquid crystal aligning layers Rolic AG (CH) 2008-10-01 EP disclosed
EP-1860094-A1 Photocrosslinkable materials Rolic AG (CH) 2007-11-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080293888-A1 Photocrosslinkable Materials DDC, PARG, ALAD KMT2A 666/4885MEN1 676/4885KDM4E 1831/4885
US-20120076952-A1 PHOTOCROSSLINKABLE MATERIALS DDC, PARG, ALAD KMT2A 666/4885MEN1 676/4885KDM4E 1831/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.