Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 3/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.38 |
| ▸ | NAE1 | Q13564 | 7/20 | 0.37 |
| ▸ | UBA3 | Q8TBC4 | 5/20 | 0.37 |
| ▸ | UBA6 | A0AVT1 | 3/20 | 0.36 |
| ▸ | SAE1 | Q9UBE0 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATG7 | O95352 | 1/20 | 0.36 |
| ▸ | UBA7 | P41226 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | GRK5 | P34947 | 1/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.34 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL867513 | 1.00 | NT5E (0.40) | NT5EBCHEAURKARPS6KB1NAE1 | |
| SCHEMBL867511 | 1.00 | NT5E (0.40) | NT5EBCHEAURKARPS6KB1NAE1 | |
| SCHEMBL867415 | 0.91 | AURKA (0.39) | BCHEAURKARPS6KB1NAE1UBA3 | |
| SCHEMBL867414 | 0.91 | AURKA (0.39) | BCHEAURKARPS6KB1NAE1UBA3 | |
| SCHEMBL867413 | 0.91 | AURKA (0.39) | BCHEAURKARPS6KB1NAE1UBA3 | |
| SCHEMBL866682 | 0.90 | NAE1 (0.49) | BCHEAURKARPS6KB1NAE1UBA3 | |
| SCHEMBL866681 | 0.90 | NAE1 (0.49) | BCHEAURKARPS6KB1NAE1UBA3 | |
| SCHEMBL866683 | 0.90 | NAE1 (0.49) | BCHEAURKARPS6KB1NAE1UBA3 | |
| SCHEMBL867185 | 0.88 | AURKA (0.38) | NT5EBCHEAURKARPS6KB1NAE1 | |
| SCHEMBL865132 | 0.82 | NAE1 (0.49) | AURKARPS6KB1NAE1UBA3UBA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120077814-A1 | SULFONAMIDE, SULFAMATE, AND SULFAMOTHIOATE DERIVATIVES | WANG ZHONG (US) | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077814-A1 | SULFONAMIDE, SULFAMATE, AND SULFAMOTHIOATE DERIVATIVES | NEDD8, NAE1, UBA3 | NT5E 685/4885BCHE 1111/4885AURKA 3108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.