Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.60 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | BACE1 | P56817 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 3/20 | 0.49 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8675617 | 1.00 | MAOB (0.60) | MAOBGSK3BBACE1RAB9ASMN1; SMN2 | |
| SCHEMBL8676691 | 1.00 | MAOB (0.60) | MAOBGSK3BBACE1RAB9ASMN1; SMN2 | |
| SCHEMBL8809160 | 0.90 | NR1H4 (0.56) | MAOBRAB9ASMN1; SMN2NPC1NR1H4 | |
| SCHEMBL9837797 | 0.85 | KDM4E (0.66) | MAOBGSK3BBACE1RAB9ASMN1; SMN2 | |
| SCHEMBL9839473 | 0.85 | KDM4E (0.66) | MAOBGSK3BBACE1RAB9ASMN1; SMN2 | |
| SCHEMBL9839479 | 0.85 | KDM4E (0.66) | MAOBGSK3BBACE1RAB9ASMN1; SMN2 | |
| SCHEMBL10800845 | 0.84 | ALDH1A1 (0.61) | MAOBSMN1; SMN2NFKB1 | |
| SCHEMBL10800841 | 0.84 | ALDH1A1 (0.61) | MAOBSMN1; SMN2NFKB1 | |
| SCHEMBL9838120 | 0.82 | KDM4E (0.61) | MAOBGSK3BBACE1RAB9ASMN1; SMN2 | |
| SCHEMBL9838123 | 0.82 | KDM4E (0.61) | MAOBGSK3BBACE1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750708-A | Pyridine compounds intermediates processes compositions and methods | ELI LILLY AND COMPANY (US) | 1998-05-12 | — | — | US | disclosed |
| US-5672609-A | POSTMENOPAUSAL SYNDROME; ANTILIPEMIC AND -CARCINOGENIC AGENTS; OSTEOPOROSIS; CARDIOTONIC AGENTS; RESTENOSIS; SIDE EFFECT REDUCTION COMPARED TO ESTROGEN | ELI LILLY AND COMPANY (US) | 1997-09-30 | — | — | US | disclosed |
| WO-1997004778-A1 | PYRIDINE COMPOUNDS, INTERMEDIATES, PROCESSES, COMPOSITIONS, AND METHODS | ELI LILLY AND COMPANY (US) | 1997-02-13 | — | — | WO | disclosed |