Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 4/20 | 0.51 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.43 |
| ▸ | GNPAT | O15228 | 2/20 | 0.42 |
| ▸ | CPB2 | Q96IY4 | 5/20 | 0.40 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.39 |
| ▸ | GSR | P00390 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.37 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.37 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL232125 | 1.00 | FOLH1 (0.51) | FOLH1SLC6A5GNPATCPB2NOD1 | |
| SCHEMBL866580 | 1.00 | FOLH1 (0.51) | FOLH1SLC6A5GNPATCPB2NOD1 | |
| Hydrochloric Acid SCHEMBL1982441 | 0.98 | FOLH1 (0.50) | FOLH1SLC6A5GNPATCPB2NOD1 | |
| Hydrochloric Acid SCHEMBL1982438 | 0.98 | FOLH1 (0.50) | FOLH1SLC6A5GNPATCPB2NOD1 | |
| SCHEMBL45765 | 0.95 | FOLH1 (0.58) | FOLH1SLC6A5GNPATCPB2GSR | |
| SCHEMBL214641 | 0.95 | FOLH1 (0.58) | FOLH1SLC6A5GNPATCPB2GSR | |
| Hydrochloric Acid SCHEMBL2166126 | 0.93 | FOLH1 (0.57) | FOLH1SLC6A5GNPATCPB2GSR | |
| Acetic Acid SCHEMBL268740 | 0.93 | FOLH1 (0.57) | FOLH1SLC6A5GNPATCPB2GSR | |
| Hydrochloric Acid SCHEMBL15914484 | 0.93 | FOLH1 (0.57) | FOLH1SLC6A5GNPATCPB2GSR | |
| SCHEMBL159460 | 0.85 | GNPAT (0.55) | FOLH1SLC6A5GNPATCPB2NOD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120076859-A1 | Targeted Lung Delivery of Citrulline and/or Another Nitric Oxide Precursor and a Method for Treatment of Pulmonary Deficiency of Nitric Oxide in Cystic Fibrosis and Other Pulmonary Diseases | ACTIVAERO GMBH (DE) | 2012-03-29 | — | — | US | disclosed |
| US-20080070952-A1 | Inhibition or Treatment of Dyskinesia | PROXIMAGEN LTD., (GB) | 2008-03-20 | — | — | US | disclosed |
| EP-1850838-A2 | INHIBITION OR TREATMENT OF DYSKINESIA | Proximagen Ltd. (GB) | 2007-11-07 | — | — | EP | disclosed |
| US-7141595-B2 | Amino benzothiazole compounds with NOS inhibitory activity | NEURAXON INC. (CA) | 2006-11-28 | — | — | US | disclosed |
| WO-2006087577-A2 | INHIBITION OR TREATMENT OF DYSKINESIA | PROXIMAGEN LTD. (GB) | 2006-08-24 | — | — | WO | disclosed |
| US-20050209291-A1 | N-(2-Amino-benzothiazol-6-yl)-ethylthiocarboximidamide or other amino benzothiazole derivatives as neuroprotectants and for the treatment of neuropathic pain | NEURAXON INC. (CA) | 2005-09-22 | — | — | US | disclosed |
| US-20030118983-A1 | Rapid screening procedure for inflammation mediators | CASSIDY RICHARD A (US) | 2003-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070952-A1 | Inhibition or Treatment of Dyskinesia | DBH, COMT, DDO | FOLH1 1148/4885SLC6A5 408/4885GNPAT 1618/4885 |
| US-20050209291-A1 | N-(2-Amino-benzothiazol-6-yl)-ethylthiocarboximidamide or other amino benzothiazole derivatives as neuroprotectants and for the treatment of neuropathic pain | GAP43, NLN, TRPV1 | FOLH1 4025/4885SLC6A5 3372/4885GNPAT 1352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.