Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 15/20 | 0.65 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8676706 | 1.00 | TBXAS1 (0.65) | TBXAS1TBXA2RCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9030628 | 0.84 | TBXAS1 (0.71) | TBXAS1TBXA2R | |
| SCHEMBL9030728 | 0.84 | TBXAS1 (0.71) | TBXAS1TBXA2R | |
| SCHEMBL9030641 | 0.84 | TBXAS1 (0.71) | TBXAS1TBXA2R | |
| SCHEMBL9032871 | 0.83 | TBXAS1 (0.70) | TBXAS1TBXA2R | |
| SCHEMBL9032879 | 0.83 | TBXAS1 (0.70) | TBXAS1TBXA2R | |
| SCHEMBL9032883 | 0.83 | TBXAS1 (0.70) | TBXAS1TBXA2R | |
| SCHEMBL8675717 | 0.83 | TBXAS1 (0.41) | TBXAS1 | |
| Hydrochloric Acid SCHEMBL9031084 | 0.82 | TBXAS1 (0.68) | TBXAS1TBXA2R | |
| Hydrochloric Acid SCHEMBL9031078 | 0.82 | TBXAS1 (0.68) | TBXAS1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5840896-A | PREPARING 2-AMINOCARBONYL-N-(4-AMINO-2,6-DICHLOROPHENYL)-4-(5,5-BIS(4-FLUOROPHENYL) -PENTYL)-1-PIPERAZINEACETAMIDE; CYCLIZATION; HYDROGENATION CATALYSIS; REDUCTIVE N-ALKYLATION | JANSSEN PHARMACEUTICA, N.V. (BE) | 1998-11-24 | — | — | US | disclosed |
| EP-0577171-A2 | Use of piperazine acetamide derivatives against reperfusion damage | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-01-05 | — | — | EP | disclosed |
| EP-0455789-A1 | METHOD OF PREVENTING OR LIMITING REPERFUSION DAMAGE. | JANSSEN PHARMACEUTICA NV (BE) | 1991-11-13 | — | — | EP | disclosed |
| WO-1991007967-A2 | METHOD OF PREVENTING OR LIMITING REPERFUSION DAMAGE | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-06-13 | — | — | WO | disclosed |