SCHEMBL9032871

SCHEMBL9032871

Fc1ccc(/C(=C/CCCCl)c2cccnc2)cc1

nearest known ligand 0.70

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TBXAS1 P24557 18/20 0.70
TBXA2R P21731 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9032883 1.00 TBXAS1 (0.70) TBXAS1TBXA2R
SCHEMBL9032879 1.00 TBXAS1 (0.70) TBXAS1TBXA2R
Hydrochloric Acid SCHEMBL9031084 0.99 TBXAS1 (0.68) TBXAS1TBXA2R
Hydrochloric Acid SCHEMBL9031078 0.99 TBXAS1 (0.68) TBXAS1TBXA2R
Hydrochloric Acid SCHEMBL9031075 0.99 TBXAS1 (0.68) TBXAS1TBXA2R
SCHEMBL9030641 0.88 TBXAS1 (0.71) TBXAS1TBXA2R
SCHEMBL9030728 0.88 TBXAS1 (0.71) TBXAS1TBXA2R
SCHEMBL9030628 0.88 TBXAS1 (0.71) TBXAS1TBXA2R
SCHEMBL8676706 0.83 TBXAS1 (0.65) TBXAS1TBXA2R
SCHEMBL8676708 0.83 TBXAS1 (0.65) TBXAS1TBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0727421-A1 Agents for improving sleep JANSSEN PHARMACEUTICA N.V. (BE) 1996-08-21 EP disclosed
US-5026853-A Sleep and cardiovascular disorders JANSSEN PHARMACEUTICA N.V. (BE) 1991-06-25 US disclosed
US-4968684-A N-ARYL-PIPERAZINEALKANAMIDE DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 1990-11-06 US disclosed
US-4880808-A SEDATIVES JANSSEN PHARMACEUTICA N.V. (BE) 1989-11-14 US disclosed
EP-0285219-A2 Method of improving sleep JANSSEN PHARMACEUTICA N.V. (BE) 1988-10-05 EP disclosed