Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7771779 | 0.93 | HTR2A (0.45) | ALDH1A1CYP3A4ADRA1ATAAR1MEN1 | |
| SCHEMBL5382666 | 0.87 | NR4A1 (0.47) | ALDH1A1HRH2HRH3SKP2MEN1 | |
| SCHEMBL5058376 | 0.87 | ALDH1A1 (0.55) | ALDH1A1CYP3A4ADRA1ATAAR1MEN1 | |
| SCHEMBL22897755 | 0.86 | ALDH1A1 (0.47) | ALDH1A1CYP3A4HRH2HRH3ADRA1A | |
| SCHEMBL23575258 | 0.83 | ESR1 (0.47) | HRH2HRH3ADRA1ATAAR1MTNR1A | |
| SCHEMBL30250416 | 0.83 | ESR1 (0.47) | HRH2HRH3ADRA1ATAAR1MTNR1A | |
| SCHEMBL5382655 | 0.82 | NR4A1 (0.45) | ALDH1A1CYP3A4SKP2MEN1MAPT | |
| SCHEMBL2019106 | 0.81 | TAAR1 (0.68) | ALDH1A1CYP3A4ADRA1ATAAR1MEN1 | |
| SCHEMBL31457326 | 0.81 | ALDH1A1 (0.46) | ALDH1A1CYP3A4SKP2MEN1MAPT | |
| SCHEMBL1911809 | 0.81 | ALDH1A1 (0.53) | ALDH1A1CYP3A4ADRA1ATAAR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5776980-A | Substituted benzenesulfonylureas and -thioureas-process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-07-07 | — | — | US | disclosed |