Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | IDO1 | P14902 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2019106 | 0.90 | TAAR1 (0.68) | ALDH1A1CYP3A4ADRA1ATAAR1MEN1 | |
| SCHEMBL27848999 | 0.88 | ALDH1A1 (0.48) | ALDH1A1CYP3A4ADRA1ATAAR1MEN1 | |
| SCHEMBL19783801 | 0.88 | CYP2D6 (0.51) | ALDH1A1CYP3A4ADRA1ATAAR1MEN1 | |
| SCHEMBL30189619 | 0.88 | CYP2D6 (0.51) | ALDH1A1CYP3A4ADRA1ATAAR1MEN1 | |
| SCHEMBL8680435 | 0.87 | ALDH1A1 (0.47) | ALDH1A1CYP3A4ADRA1ATAAR1MEN1 | |
| SCHEMBL774393 | 0.85 | ALDH1A1 (0.53) | ALDH1A1CYP3A4ADRA1ATAAR1MEN1 | |
| SCHEMBL1911809 | 0.85 | ALDH1A1 (0.53) | ALDH1A1CYP3A4ADRA1ATAAR1MEN1 | |
| SCHEMBL7771779 | 0.84 | HTR2A (0.45) | ALDH1A1CYP3A4ADRA1ATAAR1MEN1 | |
| SCHEMBL774392 | 0.83 | ALDH1A1 (0.57) | ALDH1A1CYP3A4ADRA1ATAAR1MEN1 | |
| SCHEMBL3377786 | 0.83 | ALDH1A1 (0.52) | ALDH1A1CYP3A4ADRA1ATAAR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7354928-B2 | Small molecule inhibitors targeted at Bcl-2 | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-04-08 | — | — | US | disclosed |
| US-7354928-B2 | Small molecule inhibitors targeted at Bcl-2 | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-04-08 | — | — | US | disclosed |
| US-7354928-B2 | Small molecule inhibitors targeted at Bcl-2 | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-04-08 | — | — | US | disclosed |
| US-20080058322-A1 | Small molecule inhibitors targeted at Bcl-2 | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-03-06 | — | — | US | disclosed |
| US-20080058322-A1 | Small molecule inhibitors targeted at Bcl-2 | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-03-06 | — | — | US | disclosed |
| US-20080058322-A1 | Small molecule inhibitors targeted at Bcl-2 | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-03-06 | — | — | US | disclosed |
| US-20030199489-A1 | Small molecule inhibitors targeted at BCL-2 | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2003-10-23 | — | — | US | disclosed |
| WO-2003038060-A2 | SMALL MOLECULE INHIBITORS TARGETED AT BCL-2 | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2003-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058322-A1 | Small molecule inhibitors targeted at Bcl-2 | BCL2, BCL2L1, BCL2L2 | ALDH1A1 4519/4885CYP3A4 4786/4885ADRA1A 4832/4885 |
| US-20030199489-A1 | Small molecule inhibitors targeted at BCL-2 | BCL2L1, BCL2, BCL2L2 | ALDH1A1 4435/4885CYP3A4 4808/4885ADRA1A 4815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.