Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17551834 | 0.86 | MAPT (0.59) | MAPTHTR2ASLC6A4KCNH2ALDH1A1 | |
| SCHEMBL15779290 | 0.85 | KDM4C (0.45) | MAPTHTTALDH1A1LMNAS1PR4 | |
| SCHEMBL8681232 | 0.84 | SLC6A4 (0.38) | MAPTHTR2ASLC6A4KCNH2HTT | |
| SCHEMBL3325248 | 0.82 | CYP1A2 (0.49) | MAPTHTR2ASLC6A4HTTALDH1A1 | |
| SCHEMBL1679612 | 0.82 | PDCD1 (0.50) | MAPTHTR2ASLC6A4KCNH2HTT | |
| SCHEMBL29825398 | 0.82 | PDCD1 (0.50) | MAPTHTR2ASLC6A4KCNH2HTT | |
| SCHEMBL15462235 | 0.81 | PDCD1 (0.40) | MAPTHTTALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL15777952 | 0.79 | MAPT (0.48) | MAPTALDH1A1SMN1; SMN2LMNAPSEN1 | |
| SCHEMBL15463254 | 0.79 | APLNR (0.46) | MAPTALDH1A1PDCD1CD274PDE4A | |
| SCHEMBL17625677 | 0.78 | ALDH1A1 (0.46) | MAPTALDH1A1NPSR1LMNAMRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843983-A | Diphenylethane compounds containing a saturated heterocyclic group, their preparation, and their therapeutic use | SANKYO COMPANY, LIMITED (JP) | 1998-12-01 | — | — | US | disclosed |
| EP-0790235-A1 | Diaryl alkane derivatives containing an alicyclic group, their preparation and their therapeutic and prophylactic uses | SANKYO COMPANY LIMITED (JP) | 1997-08-20 | — | — | EP | disclosed |