SCHEMBL8680951

SCHEMBL8680951

COc1cc2ccccc2c2c1OC1(C=C2)C=Cc2c(c(OC)cc3ccccc23)O1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE4D Q08499 2/20 0.43
NQO1 P15559 1/20 0.39
GPR84 Q9NQS5 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.37
TP53 P04637 1/20 0.37
CYP1A2 P05177 1/20 0.37
BRCA1 P38398 1/20 0.37
HNF4A P41235 1/20 0.37
HIF1A Q16665 1/20 0.37
MAPT P10636 3/20 0.37
ALDH1A1 P00352 3/20 0.36
NPSR1 Q6W5P4 1/20 0.36
KRAS P01116 1/20 0.36
SOS1 Q07889 1/20 0.36
PTGES O14684 3/20 0.35
ALOX5 P09917 2/20 0.35
CA12 O43570 1/20 0.35
CA1 P00915 1/20 0.35
CA7 P43166 1/20 0.35
CA9 Q16790 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7128153 0.83 PDE4D (0.40) PDE4DNQO1GPR84SMN1; SMN2TP53
SCHEMBL8685222 0.77 HTT (0.45) PDE4DSMN1; SMN2ALDH1A1CA12CA1
SCHEMBL8681967 0.75 MAPT (0.47) PDE4DGPR84SMN1; SMN2TP53CYP1A2
SCHEMBL8680232 0.73 ALDH1A1 (0.40) PDE4DSMN1; SMN2TP53CYP1A2BRCA1
SCHEMBL7888138 0.68 HTT (0.36) GPR84SMN1; SMN2MAPTALDH1A1NPSR1
SCHEMBL5913910 0.66 ALDH1A1 (0.55) GPR84SMN1; SMN2CYP1A2HIF1AMAPT
SCHEMBL1128095 0.66 NQO1 (0.56) NQO1GPR84SMN1; SMN2TP53CYP1A2
SCHEMBL8680691 0.66 ALDH1A1 (0.48) GPR84SMN1; SMN2CYP1A2HIF1AMAPT
SCHEMBL887313 0.65 GPR84 (0.74) GPR84KDM4E
Hydrochloric Acid SCHEMBL27730723 0.64 NQO1 (0.54) NQO1GPR84SMN1; SMN2TP53CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5759729-A A DRY TONER COMPRISING A RESIN, PHOTOCHROMATIC SPIROPYRAN, -OXAZINE OR -THIOPYRAN DYE AND A CHARGE CONTROL AGENT;ELECTROGRAPHY; XEROGRAPHY XEROX CORPORATION (US) 1998-06-02 US claimed
US-5759729-A A DRY TONER COMPRISING A RESIN, PHOTOCHROMATIC SPIROPYRAN, -OXAZINE OR -THIOPYRAN DYE AND A CHARGE CONTROL AGENT;ELECTROGRAPHY; XEROGRAPHY XEROX CORPORATION (US) 1998-06-02 US disclosed
US-5593486-A Photochromic hot melt ink compositions XEROX CORPORATION (US) 1997-01-14 US disclosed
US-5551973-A LIQUID CRYSTAL GEL PHASE, MICROEMULSION PHASE XEROX CORPORATION (US) 1996-09-03 US disclosed