Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.60 |
| ▸ | TUBB | P07437 | 1/20 | 0.60 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.60 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.60 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.60 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.60 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.60 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.60 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.60 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.60 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.60 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.60 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.60 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.60 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.60 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | TTK | P33981 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5386371 | 0.88 | ALOX5 (0.55) | KDM4ETUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL4488472 | 0.84 | KDM4E (0.74) | KDM4EHCRTR1ALDH1A1TTKRAB9A | |
| SCHEMBL27496466 | 0.84 | MAP2K4 (0.66) | KDM4EHCRTR1ALDH1A1TTKRAB9A | |
| SCHEMBL11749690 | 0.81 | HCRTR1 (0.58) | KDM4ETUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL31172408 | 0.81 | KDM4E (0.48) | KDM4ETUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL2866791 | 0.81 | MAP2K4 (0.69) | KDM4EALDH1A1TTKRAB9AMAPT | |
| SCHEMBL8684224 | 0.80 | KDM4E (0.58) | KDM4ETUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL29925789 | 0.80 | HCRTR1 (0.57) | KDM4ETUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL17514133 | 0.80 | HCRTR1 (0.57) | KDM4ETUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL8682391 | 0.80 | KDM4E (0.53) | KDM4ETUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760028-A | TREATING CANCER METASTASIS, DIABETIC RETINOPATHY, NEOVASCULAR GLAUCOMA, THROMBOSIS, RESTENOSIS, OSTEOPOROSIS, MACULAR DEGENERATION | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-06-02 | — | — | US | disclosed |