Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.52 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | FBP1 | P09467 | 2/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.32 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.32 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8682291 | 0.83 | AR (0.46) | ARNR1H2MEN1KMT2AMAPT | |
| SCHEMBL16230730 | 0.83 | AR (0.43) | ARNR1H2ALDH1A1TSHRNOS1 | |
| SCHEMBL5759768 | 0.83 | AR (0.42) | ARNR1H2MEN1KMT2AMAPT | |
| SCHEMBL8617994 | 0.82 | AR (0.53) | ARNR1H2MEN1KMT2AMAPT | |
| SCHEMBL26229838 | 0.79 | AR (0.40) | ARNR1H2MEN1KMT2AMAPT | |
| SCHEMBL6288482 | 0.79 | AR (0.42) | ARNR1H2MEN1KMT2AMAPT | |
| SCHEMBL8617770 | 0.79 | AR (0.50) | ARNR1H2PRKDCFBP1ALOX5 | |
| SCHEMBL27837232 | 0.78 | — | — | |
| SCHEMBL9434229 | 0.78 | AR (0.55) | ARNR1H2PRKDCALOX5 | |
| SCHEMBL31478751 | 0.77 | ALDH1A1 (0.39) | ARNR1H2MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843971-A | 1, 1-BIS (heteroazolyl) alkane derivatives and their use as neuroprotective agents | ASTRA AKTIEBOLAG (SE) | 1998-12-01 | — | — | US | claimed |
| WO-1995033747-A1 | NOVEL 1,1-BIS(HETEROAZOLYL)ALKANE DERIVATIVES AND THEIR USE AS NEUROPROTECTIVE AGENTS | ASTRA AKTIEBOLAG (SE) | 1995-12-14 | — | — | WO | claimed |
| US-5843971-A | 1, 1-BIS (heteroazolyl) alkane derivatives and their use as neuroprotective agents | ASTRA AKTIEBOLAG (SE) | 1998-12-01 | — | — | US | disclosed |
| US-5665747-A | TREATING NERVOUS SYSTEM, PSYCHOLOGICAL, AND BRAIN DISORDERS | ASTRA AKTIEBOLAG (SE) | 1997-09-09 | — | — | US | disclosed |
| EP-0765325-A1 | NOVEL 1,1-BIS(HETEROAZOLYL)ALKANE DERIVATIVES AND THEIR USE AS NEUROPROTECTIVE AGENTS | Astra Aktiebolag (SE) | 1997-04-02 | — | — | EP | disclosed |
| WO-1995033747-A1 | NOVEL 1,1-BIS(HETEROAZOLYL)ALKANE DERIVATIVES AND THEIR USE AS NEUROPROTECTIVE AGENTS | ASTRA AKTIEBOLAG (SE) | 1995-12-14 | — | — | WO | disclosed |