Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.55 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 13/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9433713 | 0.81 | AR (0.51) | ARNR1H2PRKDCALOX5 | |
| SCHEMBL9434600 | 0.79 | KCNH2 (0.44) | PRKDCALOX5KCNH2 | |
| SCHEMBL8682014 | 0.78 | AR (0.52) | ARNR1H2PRKDCALOX5 | |
| SCHEMBL7813254 | 0.76 | ALOX5 (0.60) | ALOX5 | |
| SCHEMBL9598846 | 0.76 | ALOX5 (0.70) | ALOX5 | |
| SCHEMBL9433149 | 0.73 | ALOX5 (0.52) | ALOX5 | |
| SCHEMBL9369962 | 0.73 | ALOX5 (0.60) | ALOX5 | |
| SCHEMBL8617770 | 0.72 | AR (0.50) | ARNR1H2PRKDCALOX5 | |
| SCHEMBL6288482 | 0.68 | AR (0.42) | ARNR1H2ALOX5SYK | |
| SCHEMBL16230730 | 0.67 | AR (0.43) | ARNR1H2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5283245-A | Antiinflammatory agent, antiallergens | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-02-01 | — | — | US | disclosed |
| US-5196422-A | Antiinflammatory agents, antiallergens | ICI PHARMA (FR) | 1993-03-23 | — | — | US | disclosed |
| EP-0381375-B1 | HETEROCYCLIC DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-11-11 | — | — | EP | disclosed |
| US-5089513-A | Antiinflammatory agents; antiallergens; asthma; side effect reduction | ICI PHARMA (FR) | 1992-02-18 | — | — | US | disclosed |
| US-5089495-A | Lipoxygenase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (FR) | 1992-02-18 | — | — | US | disclosed |
| EP-0381375-A1 | Heterocyclic derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-08-08 | — | — | EP | disclosed |