Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRR | Q9GZT4 | 2/20 | 0.51 |
| ▸ | ACE | P12821 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 12/20 | 0.47 |
| ▸ | PPARA | Q07869 | 10/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9359097 | 1.00 | SRR (0.51) | SRRACEHPGDTSHRGAA | |
| SCHEMBL8909660 | 1.00 | SRR (0.51) | SRRACEHPGDTSHRGAA | |
| SCHEMBL9354940 | 0.86 | MEN1 (0.49) | HPGDTSHRGAAPPARGPPARA | |
| SCHEMBL8681953 | 0.86 | MEN1 (0.49) | HPGDTSHRGAAPPARGPPARA | |
| SCHEMBL7287136 | 0.86 | KMT2A (0.58) | SRRACETSHRPPARGPPARA | |
| SCHEMBL9354821 | 0.86 | HSD17B10 (0.58) | SRRACEPPARGPPARA | |
| SCHEMBL9359129 | 0.86 | DPP4 (0.49) | SRRACEPPARGPPARA | |
| SCHEMBL9359132 | 0.86 | DPP4 (0.49) | SRRACEPPARGPPARA | |
| SCHEMBL9740620 | 0.86 | ACE (0.49) | SRRACEPPARGPPARAKMT2A | |
| SCHEMBL7278049 | 0.86 | HSD17B10 (0.58) | SRRACEPPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750696-A | HYPOTENSIVE AGENTS | JAPAN TOBACCO INC. (JP) | 1998-05-12 | — | — | US | disclosed |
| US-5688946-A | DIPEPTIDES FOR HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS | HOFFMANN LA ROCHE INC. (US) | 1997-11-18 | — | — | US | disclosed |
| EP-0656356-A1 | DIOXACYCLOALKANE COMPOUND WITH RENIN-INHIBITING ACTIVITY | JAPAN TOBACCO INC. (JP) | 1995-06-07 | — | — | EP | disclosed |
| EP-0416373-A2 | Amino acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1991-03-13 | — | — | EP | disclosed |